The zebrafish heart has been used as a basic, low-cost model to investigate the development, anatomy, and function of the heart from infancy to adulthood. It has also been established as a model for studying various heart diseases caused by various approaches. Cardiac diseases range from functional problems like arrhythmia to structural illnesses like hypertrophic heart disease, and many of them have been linked to genetic and molecular factors. Some of these genetic and molecular variables have been implicated in human cases of sudden cardiac death. This negative consequence is typical in a variety of cardiovascular diseases and can happen at any age. Unfortunately, the aetiology and physiopathology of sudden cardiac death are unknown, necessitating further research. The goal of this review was to demonstrate the benefits of using a zebrafish model to research sudden cardiac death by taking into account the genetic, molecular, and physiological information available on cardiovascular development and function throughout its life cycle. A literature search was conducted for this review utilising the PubMed database and the Google Scholar search engine, using the terms sudden cardiac death, zebrafish, arrhythmias, and cardiomyopathies combined.
Author(S) Details
Rafael Antonio Vargas
Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia and Maestría en Actividad Física para la Salud, Universidad Santo Tomás, Bogotá, Colombia.
View Book:- https://stm.bookpi.org/IDMMR-V8/article/view/5806
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