Introduction: Mitosis is a fundamental ageing process. Mitoses can be present in many different tissues and are regulated by mediators. Cancer, graft–versus–host disease, and other disorders are treated with cytokines and hormones, for example.
Our goal is to analyse existing studies on age–related mitoses, cytokines, and hormones in lymph (body fluid), particularly in the thoracic duct lymph (TDL) in healthy people, and to apply it to new treatment development.
Methods: We searched the PubMed/Medline, World Cat, Google, and Index Copernicus databases for publications published in the last four decades.
Results: In normal TDL, three papers described the morphological characteristics and quantitative changes in age-related mitoses. TDL lymphocytes were studied quantitatively and morphologically in healthy and thyroxin-treated persons in one study. Several investigations were undertaken on the physiology of angiotensins, insulin, and steroid hormones. Proliferation and mitosis mediators have been the subject of a lot of recent research. The antigen–stimulation and other effects of interleukins are being investigated in lymph. It was revealed that age has an effect on the immune system, notably mitoses. Despite progress in the field of drug design, there is a sense that some reductionist strategies have failed to tackle specific difficulties. Several complex multistep schemes must be performed, cytotoxicities must be regulated, and the results must be compared in order to develop a medicine.
Conclusion: The information presented above demonstrates that the immune system changes with age, both in terms of normalcy and impact. There hasn't been any research into the differences and changes in TDL mitotic mediators in mature and immature organisms. It is necessary to design new medication components. Differences in TDL mitotic mediators between healthy babies (neonatal, immature) and adults (mature) could be utilised to produce new treatments for cancer, graft–versus–host disease, and other disorders, according to the researchers.Author(S) Details
A. Kuznetsov
Department of Human Anatomy, Novosibirsk State Medical University, Russia.
Y. Almabayev
b Department of the Clinical Anatomy, Kazakh National Medical University, Kazakhstan.
I. Fackhradiev
Laboratory of Experimental Medicine, Kazakh National Medical University, Kazakhstan.
A. Almabaeva
Department of the Human Anatomy with OS, Medical University Astana, Kazakhstan.
J. Serikpayev
Human Anatomy OS, Medical University Astana, Kazakhstan.
B. Tanabayev
Department Morphological, South Kazakhstan State Pharmaceutical Academy, Kazakhstan.
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