Endometriosis is currently treated with certain estrogen-regulatory medications. Endometriosis is a condition in which endometrial tissue grows outside of the uterus. However, these medical procedures have serious side effects, and patients who want to get pregnant will be unable to do so. The updated American Fertility Society (r-AFS) scores were matched between patients with and without leukotriene receptor antagonist (LTR-A) treatment to assess morphological changes and clinical symptoms. The r-AFS score was substantially lower in LTR-A-treated situations. Furthermore, there was an important link between the r-AFS score and the LTR-A treatment time. Medical conditions diminished in treated cases, and some patients became pregnant. Lesions in LTR-A-treated cases demonstrated apoptotic fibroblasts and collagen fibre degeneration morphologically. LTR-As had important therapeutic benefit for the treatment of human endometriosis, according to our results. Anti-LT therapy tends to be effective not only for treating clinical symptoms and lesions, but also for boosting fertility.
Author (s) DetailsMasao Sugamata
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan
Tomomi Ihara
Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan
Ichiro Uchiide
Department of Obstetrics and Gynecology, Japan Red Cross Hospital Omori, Tokyo, Japan
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