Because of the impermeable structure of human nails, onychomycosis is a common and difficult to cure fungus infection of the nails. Because topically applied antifungals are unable to permeate this structure, treatment regimens frequently turn to systemic antifungals, which come with their own set of side effects. According to a recent clinical trial, mechanical fenestration of the nail with an intelligent nail drill could be a viable solution to this issue. An in vitro model of antifungal drug transungual administration is given in this paper.  Real nail tissue and an inline flow system are used in this system. After 42 days, this technique was used to measure transungual distribution of ciclopirox, and it was discovered that nail fenestration enhanced drug delivery by 3–4 times. This research backs up the idea that nail fenestration should be accepted as a pretreatment for onychomycosis, and it also provides an opportunity to test new medications or formulations to attack the disease. Prior to clinical trials, the in vitro model reported here would be an excellent approach for directly measuring transungual distribution of antifungal drugs.

Author (s) Details

Damian Cordoba Díaz
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Marta Elena Losa Iglesias
Facultad Ciencias de la Salud, Universidad Rey Juan Carlos, 28933 Madrid, Spain.

Ricardo Becerro de Bengoa Vallejo
Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Manuel Cordoba Diaz
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.


View Book  : - https://stm.bookpi.org/TIPR-V3/article/view/1144