The enzyme activity features of thymidilate "salvage route" synthesis and adenosine catabolism in blood serum and cancer tissues from solid nearby tumours of various localizations were compared. The goal of this study was to look at the diagnostic value of thymidilate metabolism enzymes and adenosine deaminase (ADA) activity, as well as their relationship to tumour growth. Methods: The radioisotope technique and spectrophotometry were used to determine enzyme activity in 169 patients' blood serum and lymphocytes. The activity of thymidine phosphorylase in blood serum is lower in cancer patients than in healthy people, according to the findings. It was accompanied by an increase in the activities of thymidine kinase (TK) and adenosine deaminase (ADA). The characteristics of enzyme activity were shown to be related to age and illness stage. The activity of enzymes changed depending on the success of chemotherapy and tumour elimination. The ADA activity properties of lymphocytes can be a useful indicator of their malfunction. Conclusion: Our findings imply that studying individual enzyme activity dynamics in blood serum could be useful for illness recurrence detection and drug treatment optimization.
Author(s) DetailsBerta G. Borzenko
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.
Elena M. Bakurova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.
Kseniia A. Mironova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.
Ulia D. Tursunova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.
View Book :- https://stm.bookpi.org/HMMR-V10/article/view/1120
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