Is a cell a complex coacervate with distribution coefficients and adsorption coefficients as the primary physical–chemical characteristics, allowing for low-entropy bioenergetics based on coherence, as Schrödinger proposed in 1944? Is it possible that a cell contains ordinary water in solution with tiny solutes like K+, separated by a membrane containing ion-pumps that must constantly combat passive leaks? The latter viewpoint is known as "membrane-(pump)-theory" (MPT), which is still widely accepted in modern physiology and cell biology but contradicts numerous recent findings on intrinsically disordered proteins, membrane-less organelles, living systems' (quantum) coherence, and a slew of other key findings. It is not often known that during the 1960s and 1970s, Ling totally falsified MPT and produced an adsorption and coherence-based coacervate model for the live cell, complete with a set of experimentally confirmed new equations. All of the fundamental aspects of his so-called "association-induction-hypothesis" (AIH) have been proven in the lab. The goal of this paper is to show that the AIH is a good guide for interpreting many current physiological, physical-chemical, and physical data of live cells and sub-cellular systems, particularly those on coherent behaviour, that are incompatible with MPT. It will be demonstrated why we urgently require Ling's new bio-energetics and must reject MPT.
Author(s) DetailsLaurent Jaeken
Department of Applied Engineering, Karel de Grote University College, Antwerp University Association, Antwerp, Belgium.
View Book :- https://stm.bookpi.org/CACB-V5/article/view/1095
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