The Greatest Error in Biological Sciences, Started in 1930 and Continuing Up to Now, Generating Numerous Profound Misunderstandings in Almost All Fields of Biology | Chapter 13 | Current Advances in Chemistry and Biochemistry Vol. 5

 Is a cell a complex coacervate with distribution coefficients and adsorption coefficients as the primary physical–chemical characteristics, allowing for low-entropy bioenergetics based on coherence, as Schrödinger proposed in 1944? Is it possible that a cell contains ordinary water in solution with tiny solutes like K+, separated by a membrane containing ion-pumps that must constantly combat passive leaks? The latter viewpoint is known as "membrane-(pump)-theory" (MPT), which is still widely accepted in modern physiology and cell biology but contradicts numerous recent findings on intrinsically disordered proteins, membrane-less organelles, living systems' (quantum) coherence, and a slew of other key findings. It is not often known that during the 1960s and 1970s, Ling totally falsified MPT and produced an adsorption and coherence-based coacervate model for the live cell, complete with a set of experimentally confirmed new equations. All of the fundamental aspects of his so-called "association-induction-hypothesis" (AIH) have been proven in the lab. The goal of this paper is to show that the AIH is a good guide for interpreting many current physiological, physical-chemical, and physical data of live cells and sub-cellular systems, particularly those on coherent behaviour, that are incompatible with MPT. It will be demonstrated why we urgently require Ling's new bio-energetics and must reject MPT.

Author(s) Details

Laurent Jaeken
Department of Applied Engineering, Karel de Grote University College, Antwerp University Association, Antwerp, Belgium.

View Book :- https://stm.bookpi.org/CACB-V5/article/view/1095

DNA and RNA in the Context of the ‘Colloid-Coherence’ Paradigm of Cell Physiology | Chapter 11 | Recent Research Advances in Biology Vol. 7

 Direct observations of complex colloid properties and cell phase-transition behaviour, as well as observations of coherent behaviour, are now available. Since it is based on the untenable physics of diluted solutions with a ‘steady state non-equilibrium' bioenergetics as a result, the still-dominant ‘membrane-pump-theory' must be abandoned entirely, with all its repercussions. It should be replaced by a modern physiology based on colloidal physics that allows for coherent behaviour, a new "colloid-coherence" perspective with a "low-entropy driven equilibrium thermodynamic." Fortunately, such a viewpoint already exists: G.N. Ling's "association-induction theory" thoroughly elucidates it. This theory quantifies protoplasmic processes by gaining a better understanding of how protein, water, ions, and regulating ligand ensembles work together as functionally coherent 'nano-protoplasmic units.' This analysis is the first attempt to see whether this broad, well-formulated hypothesis holds true for DNA and RNA as well.

Author (s) Details

Laurent Jaeken
Department of Applied Engineering, Karel de Grote University College, Antwerp University Association, Antwerp, Belgium.

View Book :- https://stm.bookpi.org/RRAB-V7/article/view/843