Formulation and in-vitro Evaluation of Theophylline Floating Tablets | Chapter 15 | Technological Innovation in Pharmaceutical Research Vol. 3

 The application of technology's principles to overcome medication formulation issues and the presentation of selected potently beneficial medications has been promoted as technology continues to gain traction in the medical sciences. Our team used a synthetic polymer to create a floating drug delivery system for theophylline hydrochloride and then investigated the influence of polymer concentration on tablet buoyancy and drug release parameters in the study provided in this chapter. The polymer hydroxypropyl methylcellulose (HPMC) was employed in three formulation batches of floating tablets at varied concentrations of 15% (F1), 20% (F2), and 30% (F3). The method used was wet granulation, with sodium bicarbonate and citric acid as the gas generators. The granules' and floating tablets' physical qualities were assessed. The tablet's physicomechanical properties, buoyancy, and swelling characteristics were also investigated. The drug release research was carried out according to the USP I (basket technique) for 8 hours at 50 rpm in 900 ml 0.1N HCl. At a set period, samples were taken and analyzed with a UV spectrophotometer at a wavelength of 271 nm. A one-way analysis of variance was used to statistically examine all of the data collected (ANOVA). P0.05 was used to determine whether the differences between means were significant. The results showed that increasing the polymer (HPMC) concentration raised the swelling index and decreased the floating lag time significantly (p0.05), but had no influence on the overall floating time. For formulations F1, F2, and F3, the percentage medication release at the end of 8 hours was 100 percent, 98.2 percent, and 96.13 percent, respectively. The Higuchi kinetics model of drug release was used in all three formulations, and the mechanism of drug release was non Fickian diffusion with exponents of 0.46, 0.51, and 0.56 for each batch. Batch F3 outperformed batches F1 and F2 in terms of drug control and floating properties. The concentration of polymers had an impact. the commencement of floating and theophylline's regulated release

Author (s) Details

E. I. Akpabio
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

D. E. Effiong
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

T. O. Uwah
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

G. Jacob
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

View Book :- https://stm.bookpi.org/TIPR-V3/article/view/1158