Formulation and In –Vitro Evaluation of Bilayer Tablet of Atenolol for Biphasic Drug Release: Experimental Investigation| Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 2

The purpose of this study was to create a bilayer atenolol tablet for biphasic drug release in order to increase bioavailability and absorption in the lower GI tract.

The super disintegrants croscarmellose sodium and sodium starch glycolate were utilised in the formulation of instant release crosspovidone, which was then compressed directly. For the sustained release phase, several grades of HPMC k4 M, HPMC K15 M, Gum Tragacanth, Gum Acacia, Guar gum, and Ethyl cellulose are employed. Preformulation investigations were carried out prior to compression. The compressed bilayer tablets were tested for weight variation, size, hardness, friability, drug content, disintegration time, and in-vitro drug release using a USP dissolving device type 2(paddle).

Conclusion and Findings: The regression coefficients value (r2) for the IR3 formulation is 0.994. The findings showed that first-order drug release kinetics are followed by release kinetics. The IR3 formulation released 95 percent of the medication in 30 minutes, with a regression coefficients value (r2) of 0.994. It contains a 5% w/w crosspovidone content. The regression coefficients value (r2) for the formulation F9 is 0.992. The findings suggested that drug release kinetics are governed by the Zero order rule. After 12 hours, the F9 formulation with HPMC K15M and Gum acacia (1:1) revealed 91.20 percent drug release. Formulation IR3F9 demonstrated drug release for bilayer tablets with a quicker release layer comprising 5% w/w crospovidone and a sustained release layer including HPMC and guar gum (1:1). Formulation IR3F9 revealed a swelling index of 206 percent, a floating lag time of 2 minutes, and a total floating time of 12 hours. The dissolution profile for the IR3F9 formulation of Bilayer tablets shows a favourable relationship between cumulative drug release and time. Up to 12 hours, the release pattern indicated 95.23 percent.

Author(s) Details:

Tarun Parashar,
Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.

Soniya Rani,
Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.

Please see the link here: https://stm.bookpi.org/CAPR-V2/article/view/6575

Formulation and in-vitro Evaluation of Theophylline Floating Tablets | Chapter 15 | Technological Innovation in Pharmaceutical Research Vol. 3

 The application of technology's principles to overcome medication formulation issues and the presentation of selected potently beneficial medications has been promoted as technology continues to gain traction in the medical sciences. Our team used a synthetic polymer to create a floating drug delivery system for theophylline hydrochloride and then investigated the influence of polymer concentration on tablet buoyancy and drug release parameters in the study provided in this chapter. The polymer hydroxypropyl methylcellulose (HPMC) was employed in three formulation batches of floating tablets at varied concentrations of 15% (F1), 20% (F2), and 30% (F3). The method used was wet granulation, with sodium bicarbonate and citric acid as the gas generators. The granules' and floating tablets' physical qualities were assessed. The tablet's physicomechanical properties, buoyancy, and swelling characteristics were also investigated. The drug release research was carried out according to the USP I (basket technique) for 8 hours at 50 rpm in 900 ml 0.1N HCl. At a set period, samples were taken and analyzed with a UV spectrophotometer at a wavelength of 271 nm. A one-way analysis of variance was used to statistically examine all of the data collected (ANOVA). P0.05 was used to determine whether the differences between means were significant. The results showed that increasing the polymer (HPMC) concentration raised the swelling index and decreased the floating lag time significantly (p0.05), but had no influence on the overall floating time. For formulations F1, F2, and F3, the percentage medication release at the end of 8 hours was 100 percent, 98.2 percent, and 96.13 percent, respectively. The Higuchi kinetics model of drug release was used in all three formulations, and the mechanism of drug release was non Fickian diffusion with exponents of 0.46, 0.51, and 0.56 for each batch. Batch F3 outperformed batches F1 and F2 in terms of drug control and floating properties. The concentration of polymers had an impact. the commencement of floating and theophylline's regulated release

Author (s) Details

E. I. Akpabio
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

D. E. Effiong
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

T. O. Uwah
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

G. Jacob
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Uyo, Nigeria.

View Book :- https://stm.bookpi.org/TIPR-V3/article/view/1158