Formulation and In –Vitro Evaluation of Bilayer Tablet of Atenolol for Biphasic Drug Release: Experimental Investigation| Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 2

The purpose of this study was to create a bilayer atenolol tablet for biphasic drug release in order to increase bioavailability and absorption in the lower GI tract.

The super disintegrants croscarmellose sodium and sodium starch glycolate were utilised in the formulation of instant release crosspovidone, which was then compressed directly. For the sustained release phase, several grades of HPMC k4 M, HPMC K15 M, Gum Tragacanth, Gum Acacia, Guar gum, and Ethyl cellulose are employed. Preformulation investigations were carried out prior to compression. The compressed bilayer tablets were tested for weight variation, size, hardness, friability, drug content, disintegration time, and in-vitro drug release using a USP dissolving device type 2(paddle).

Conclusion and Findings: The regression coefficients value (r2) for the IR3 formulation is 0.994. The findings showed that first-order drug release kinetics are followed by release kinetics. The IR3 formulation released 95 percent of the medication in 30 minutes, with a regression coefficients value (r2) of 0.994. It contains a 5% w/w crosspovidone content. The regression coefficients value (r2) for the formulation F9 is 0.992. The findings suggested that drug release kinetics are governed by the Zero order rule. After 12 hours, the F9 formulation with HPMC K15M and Gum acacia (1:1) revealed 91.20 percent drug release. Formulation IR3F9 demonstrated drug release for bilayer tablets with a quicker release layer comprising 5% w/w crospovidone and a sustained release layer including HPMC and guar gum (1:1). Formulation IR3F9 revealed a swelling index of 206 percent, a floating lag time of 2 minutes, and a total floating time of 12 hours. The dissolution profile for the IR3F9 formulation of Bilayer tablets shows a favourable relationship between cumulative drug release and time. Up to 12 hours, the release pattern indicated 95.23 percent.

Author(s) Details:

Tarun Parashar,
Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.

Soniya Rani,
Uttaranchal Institute of Pharmaceutical Sciences, Dehradun, Uttarakhand, India.

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