The goal of this study was to look at the pathophysiology of Dilated Cardiomyopathy (DCM) from a morphological standpoint. On explanted hearts from DCM patients, scanning electron and polarised light microscopy examinations were undertaken to evaluate the architecture of the endocardium. Tissue samples were taken from four male (average age 72.21 years) and two female DCM patients (63.14years). The research included patients with DCM who were on transplant waiting lists and were clinically classified as stage NYHA III-IV. SEM and polarised light microscopy were used to examine the hearts of individuals who had their hearts removed for cardiac transplantation. The endocardial layer's basement membrane was extensively desquamated, revealing isolated island-like cell formations. Abrasion of endothelial cells, development of filiform and lamellar Lambl's excrescences, locally well-defined elevations above the intact endothelium, calcium deposits, and hyperplasia of collagen fibres were all seen. Micelle-like structures were also seen.
Sheila Fatehpur
Department of Vascular Surgery, OWl University, Campus Lemgo, Germany.
Michael Schultz
Institute for Anatomy, University of Göttingen, Göttingen, Germany.
Peter Schwartz
Institute for Anatomy, University of Göttingen, Göttingen, Germany.
Masoud Mirzaie
Department of Vascular Surgery, OWl University, Campus Lemgo, Germany.
View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6906
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