New calcium phosphate cements (CPCs) have been discovered with promising physical properties for dental applications such as perforation repairs. However, there is a scarcity of data on the biological properties of these new materials, especially in long-term settings. We investigated the biological features of three distinct varieties of CPCs in a four-week in vitro cytotoxicity test. A calcium phosphate paste comprising 60% tetracalcium phosphate, 30% dicalcium phosphate dihydrate, and 10% tricalcium phosphate was mixed with one of three aqueous solutions of citric acid, lactic acid, or malic acid to make Types I, II, and III CPCs. For cytotoxicity testing, the specimens were put in contact with HGF-grown cells, and cell mitochondrial function was assessed using the MTT assay four times points (24h, 1wk, 2wk, 3wk, 4wk). In terms of mitochondrial activity, Type I had attained statistical parity with the Teflon control after four weeks. Type II had become indistinguishable from the Teflon Control by the third week, which was followed by a relapse. When compared to the Teflon control, Type III was initially dangerous, but after four weeks, it improved considerably (P 0.05) by >87 percent. Calcium hydroxide (Life) was cytotoxic during the duration of the four-week investigation. Type I and Type III have the proper biologic features for endodontic applications. CPCs may therefore drastically improve the prognosis of teeth with furcation holes.
Author(S) Details
Rania M. Khashaba
Department of Oral Biology, Medical College of Georgia, Augusta, GA, USA. Department of Orthopedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA, USA and Department of Dental Materials, Misr International University(MIU), Cairo, Egypt.
View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6904
No comments:
Post a Comment