Only physiologically inert carriers have been employed to produce solid dispersion with better dissolution of poorly soluble medicines in previous research. In this investigation, a new drug–drug solid dispersion technique was used to make solid dispersions in proportions close to commercial hydrochlorothiazide and captopril (HCT-CAP) combination formulations. By kneading, the weakly soluble hydrochlorothiazide was firmly disseminated in soluble captopril. TLC, spectrophotometric assay, infrared spectra, DSC, and X-ray diffractometry were used to characterise the solid dispersion. Solubility tests were used to determine the effect of captopril on hydrochlorothiazide solubility. The in vitro dissolving properties of the solid dispersions were investigated, and the findings were compared to those of physical mixes of HCT-CAP and pure hydrochlorothiazide. Hydrochlorothiazide dissolution from solid dispersions was shown to be quicker than physical mixes and pure medication. Particle size reduction, microenvironmental solubilisation, changes in the crystalline structure of hydrochlorothiazide, and the creation of solid solution are the most likely processes for increased hydrochlorothiazide dissolution.
S. Padma Priya,
Department of Pharmaceutics Madras Medical College, Park town, Chennai-600 003, Tamil Nadu, India and Department of Pharmaceutics, College of Pharmacy, MTPG & RIHS, Pondicherry 605006, India.
N. N. Rajendran,
Department of Pharmaceutics Madras Medical College, Park town, Chennai-600 003, Tamil Nadu, Indiam and Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal 637205, India.
Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6950
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