Liquisolid Technology: A Strategy for Dissolution Enhancement of BCS Class II Drugs| Chapter 10 | Current Overview on Pharmaceutical Science Vol. 2

 The current review was used to find out the function of liquisolid technology to upgrade the rate of dissolution of mosapride citrate (BCS class II). Different Liquisolid formulations were prepared by utilizing polyethylene glycol 400 as a non-volatile fit, Avicel PH 102 as a carrier and Aerosil 200 as a covering material. Liquisolid tablets ware from FTIR, DSC, XRD and in-vitro dissolution studies. Characterisation studies registered that interactions were missing between drug and carrier, decline in the crystallinity and that will support further the augmentation of solubility and rate of dissolution. The optimised expression showed a important increase in dissolution that is, 99.69±1.47% in 30 min distinguished to directly compressible tablets (31.48±1.58%). DE (dissolution effectiveness) was increased from 15.16 % for direct condensation tablet to 70.5% for mosapride citrate liquisolid tablets. MDT (mean death time) of mosapride citrate was considerably reduced from 57.27 brief time period for direct compression tablet to 7.58 brief time period for optimized expression indicating faster release of drug. Liquisolid tablets maybe a promising form for of improvement of solubility, augmentation of dissolution and bioavailability of mosapride citrate.

Author(s) Details:

Bhaskar Daravath,
Department of Pharmaceutics, GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad, Telangana-502329, India.

Sateesh Kumar Vemula,
Department of Pharmaceutics, MAK College of Pharmacy, Moinabad, Ranga Reddy, Telangana -501504, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9172

A Comprehensive Review on Pharmaceutical Nanosuspension - as a Nanotechnology Tool for Solubility Enhancement | Chapter 1 | Challenges and Advances in Pharmaceutical Research Vol. 9

 Generally, depressed bioavailability is one of the important problems associated with poorly dissolved drugs. This becomes more worried problem in the case of drugs which are poorly dissolved in both liquid and non-aqueous publishing. To avoid all these problems, nanotechnology methods have been made acquainted which is gaining much interest in reconstructing the solubility of poorly soluble drugs. Use of nanosuspension arose as a prominent, appealing and promising alternative for efficient childbirth of such type of hydrophobic drugs. It is working for the development of the novel drug formulations and they have emerged as a favorable strategy for improving the solubility of the hydrophobic drugs due to their singular advantages. Bioavailability, stability and solubility of drugs are the determinants that can be revised by the nanosuspension science. Reducing the drug particle size into substitute-micron size leads to a notable increase in the separation rate and they interact with the corpse at sub-natural scales with the large size of specificity, altering pharmacokinetics of drug and reconstructing drug efficacy and security. Nanosupension methods proved to gain maximal healing efficacy accompanying minimal side effects and their singular features have allowed their usage in various portion of drug or other consumable forms. They are commercially prepared by press homogenization, media contents, and emulsification. Extensive efforts are being put into this field to longer their applications in the station specific drug delivery in the way that ocular, pulmonary and parenteral routes. This review item describes the readiness methods, characterization of nanosuspension containing its benefits, displayed formulations and its pharmaceutical requests.

Author(s) Details:

S. Naveen Taj,
Department of Pharmaceutics, Sri Padmavati Mahila Visvavidyalayam, [Women’s University], Tirupati – 517502, Andhra Pradesh [A.P], India.

Y. Kavya,
Sri Padmavati Mahila Visvavidyalayam, Women’s University, India.

T. Chandna Shrinivaasiny,
Sri Padmavati Mahila Visvavidyalayam, Women’s University, India.

M. Dakshayani,
Sri Padmavati Mahila Visvavidyalayam, Women’s University, India.

K. Anitha Lakshmi,
Sri Padmavati Mahila Visvavidyalayam, Women’s University, India.

Please see the link here: https://stm.bookpi.org/CAPR-V9/article/view/8670

A Novel Captopril-hydrochlorothiazide Solid Dispersion| Chapter 10 | Challenges and Advances in Pharmaceutical Research Vol.3

Only physiologically inert carriers have been employed to produce solid dispersion with better dissolution of poorly soluble medicines in previous research. In this investigation, a new drug–drug solid dispersion technique was used to make solid dispersions in proportions close to commercial hydrochlorothiazide and captopril (HCT-CAP) combination formulations. By kneading, the weakly soluble hydrochlorothiazide was firmly disseminated in soluble captopril. TLC, spectrophotometric assay, infrared spectra, DSC, and X-ray diffractometry were used to characterise the solid dispersion. Solubility tests were used to determine the effect of captopril on hydrochlorothiazide solubility. The in vitro dissolving properties of the solid dispersions were investigated, and the findings were compared to those of physical mixes of HCT-CAP and pure hydrochlorothiazide. Hydrochlorothiazide dissolution from solid dispersions was shown to be quicker than physical mixes and pure medication. Particle size reduction, microenvironmental solubilisation, changes in the crystalline structure of hydrochlorothiazide, and the creation of solid solution are the most likely processes for increased hydrochlorothiazide dissolution.

Author(s) Details:

S. Padma Priya,
Department of Pharmaceutics Madras Medical College, Park town, Chennai-600 003, Tamil Nadu, India and Department of Pharmaceutics, College of Pharmacy, MTPG & RIHS, Pondicherry 605006, India.

N. N. Rajendran,
Department of Pharmaceutics Madras Medical College, Park town, Chennai-600 003, Tamil Nadu, Indiam and Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal 637205, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6950

Advanced Formulation Techniques to Enhance Solubility, Dissolution and Bioavailability of Poorly Water- Soluble Drugs| Chapter 8 | Challenges and Advances in Pharmaceutical Research Vol.1

The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. For a medicine to display maximum pharmacological response, this is considered a primary parameter. Poor aqueous-soluble drugs may have slow dissolving and inadequate absorption, resulting in low bioavailability. In designing formulations, the drug's dissolving and solubility properties are critical. As a result, several approaches such as pH modification, micronization, solid dispersion, Supercritical fluid recrystallization, complexation, surfactant usage, co-solvency, precipitation, and nanotechnology are used to improve medication solubility. The primary goal of this research is to provide an overview of ways for improving the solubility, dissolution, and bioavailability of low water soluble pharmaceuticals, as well as the importance of Green chemistry in nanotechnology for the production of diverse nanosized formulations.

Author(s) Details:

G. S. Annammadevi,
Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India.


V. Lavanya,
Mother Teresa College of Pharmacy, Affiliated to Osmania University, Hyderabad, India.

Please see the link here: https://stm.bookpi.org/CAPR-V1/article/view/6239

Investigating the Influence of pH on Drug Release from Zidovudine Matrices Containing Different Grades of Hydroxypropyl Methyl Cellulose | Chapter 02 | Challenges and Advances in Chemical Science Vol. 6

 Using a variety of hydroxypropyl methylcellulose grades, the current study analyses the effect of a multimodal dissolving profile on the drug release of zidovudine-containing sustained-release hydrophilic matrices. Zidovudine is commonly used to treat AIDS, either alone or in combination with other antiviral medications. It was the first anti-HIV treatment to earn FDA approval for clinical usage. Matrixes were constructed using a combination of multiple grades of HPMC, including HPMCK4M and HPMCK15M, to maintain the medication's release. In order to imitate the in-vivo condition, in-vitro multimodal dissolution investigations were conducted. The drug's exposure from the stomach to the intestine/colon determines the pH/buffer. pH fluctuations have an effect on drug breakdown and release for absorption, according to the study. Matrices also allow for a very controlled delivery of the medication zidovudine over a long period of time.

Author(S) Details

Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, 452001, India.

View Book:- https://stm.bookpi.org/CACS-V6/article/view/4347

Isolation of Compounds from the Aqueous Methanol Extract of Cissus javana DC Leaves and Determination of Its Trace Element Content through Wet Digestion | Chapter 11 | Current Advances in Chemistry and Biochemistry Vol. 5

 The aqueous methanol extract of the leaves of Cissus javana DC, which is commonly used in Manipur, India for the breakdown and evacuation of kidney stones, yielded a novel alcohol. Stigmasterol, Stigmasterol glucoside, and other well-known substances Onocer-7-ene 3α,21β-diol, β-amyrin-[olean12(13)-en-3-one] were extracted from the same methanol extract as well. The significance of trace elements in the ethno medicinal properties of the plant is reflected in the trace element content of the plant leaf. The plant leaf was discovered to have unusually high calcium (2960 mg/100 g), magnesium (465 mg/100 g), and iron (520 mg/100 g) levels.

Author(s) Details

Bimola Devi Asem
Department of Chemistry, Modern College, Imphal-795 005, India.

Warjeet Singh Laitonjam
Department of Chemistry, Manipur University, Canchipur-795 003, India.

Ibopishak Singh Oinam
Department of Chemistry, Modern College, Imphal-795 005, India.

T. H. Jeena
Department of Chemistry, Modern College, Imphal-795 005, India.

View Book :- https://stm.bookpi.org/CACB-V5/article/view/1093

Other Oxides Pre-removed from Bangka Tin Slag to Produce a High Grade Tantalum and Niobium Oxides Concentrate: An Advance Study | Chapter 12 | New Ideas Concerning Science and Technology Vol. 9

Indonesia, as the world's second-largest tin producer, has a byproduct of tin output. Tin slag containing tantalum pentoxide (Ta2O5) and niobium pentoxide is one of the byproducts (Nb2O5). Since tantalum and niobium are among the 14 essential materials, recovering them from tin slag would be a viable alternative. The recovery of tantalum pentoxide and niobium pentoxide from tin slag is the subject of this research. One portion of the tin slag sample was sieved only (BTS), while the other was roasted at 900°C, quenched in water, and sieved (BTS-RQS). Thermo gravimetric analysis (TGA) and X-ray Florence were used to classify samples BTS and BTS-RQS (XRF). The BTS-RQS sample was dissolved in hydrofluoric acid (HF) and hydrochloric acid (HCl), washed with distilled water, and then dissolved in sodium hydroxide (NaOH). XRF was used to identify each sample. The BTS sample had the highest recovery of 0.3807 and 0.6978 percent for Ta2O5 and Nb2O5, respectively, from a particle size of -1.00+0.71 and a fraction of 47.29 percent, while the BTS-RQS sample had the highest recovery of 0.3931 and 0.8994 percent for Ta2O5 and Nb2O5, respectively, from a particle size of -0.71+0350 and a fraction of 21%. Tantalum pentoxide and niobium pentoxide have a ratio of 2.01 and 2.09, respectively, when BTS-RQS is dissolved in 8 percent hydro fluoride acid. The yield ratios for tantalum pentoxide and niobium pentoxide are 1.60 and 1.84, respectively, for the sample BTS-RQS, which was dissolved first with 6M hydrochloric acid, washed with distilled water, and then dissolved with sodium hydroxide 10M. In this analysis, it was discovered that dissolving with 8% hydrofluoric acid produces the best ratio.

Author (s) Details
 
Dr. S. Permana
Centre of Mineral Processing and Corrosion Research, Metallurgical and Materials Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia.

Prof. J. W. Soedarsono
Centre of Mineral Processing and Corrosion Research, Metallurgical and Materials Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia.

Dr. A. Rustandi
Centre of Mineral Processing and Corrosion Research, Metallurgical and Materials Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia.

Dr. A. Maksum
Centre of Mineral Processing and Corrosion Research, Metallurgical and Materials Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia and Mechanical Engineering Department, Politeknik Negeri Jakarta, Depok 16425, Indonesia.

I. Susanto
Mechanical Engineering Department, Politeknik Negeri Jakarta, Depok 16425, Indonesia.

View Book :- https://stm.bookpi.org/NICST-V9/issue/view/56

Research on Aloe vera Mucilage as Solubility Enhancer in Tablet Formulation | Chapter 12 | Current Topics in Medicine and Medical Research Vol. 6

 

The present study evaluates the synthesis of water-insoluble compounds into tablets with a sustained release matrix and the effect of aloe vera gel powder on the dissolution and other physical properties of tablets with the SR matrix. As a polymer, HPMC and ethyl cellulose were used and various  The concentration of aloe vera gel powder used as the enhancer of dissolution. By direct compression process, sustained release matrix tablets were formulated and subjected to various quality control studies as per  The official Guidelines for Pharmacopoeia. The tablet formulation that has been produced complies with the monograph. The findings suggest that the dissolution of curcumin is stimulated by aloe vera. Kinetics of dissolution indicate that all the formulation followed the model of Korsemayer Peppas by anomalous diffusion  Mechanism. To conclude, the dissolution enhancer of aloe vera gel powder can be used to increase the drug absorption of water-insoluble products.

Author (s) Details

Dr. Habibur Rahman
Faculty of Pharmaceutical Sciences, UCSI University, Malaysia and PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

Dr. Telny Thomas Chungath
Chemists College of Pharmaceutical Sciences and Research, Ernakulum, Kerala, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/272

Spherical Agglomerates - Technique of Particle Designing | Chapter 2 | Trends in Pharmaceutical Research and Development Vol.3

Spherical agglomeration is one of the novel technique used to increase the solubility and dissolution
rate of poorly soluble drug. Spherical agglomeration process improves the flowability and
compressibility of drug. Spherical agglomeration is multiple unit process in which crystallization,
agglomeration and spheronization can be carried out simultaneously. Formulated crystals can be
called as spherical agglomerates. Spherical crystallization technique has been successfully utilized for
improving of flowability and compressibility of drug. This technique may enable crystalline forms of a
drug to be converted into different polymeric form having better bioavailability. Design layout for 22
factorial designs design is applied to prepare different batches from F1 to F4 with appropriate
quantity. Solvent change method is applied for the crystallization process were speed of rotation was
adjusted as per the design layout. The particles further evaluated with different parameters. SEM of
standard batch was evaluated with size of particle. At last it was found that spherical agglomeration is
one of the technique through which we can design the particle with shape, we can increase solubility
of drug as well as dissolution and we can prepare different sized particles also.

Author (s) Details

Swapnil Shankar Patil
Department of Pharmaceutics, Annasaheb Dange College of B. Pharmacy, Ashta, Tal–Walwa, Sangli-416 301, Maharashtra, India.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/222