Spherical agglomeration is one of the novel technique used to increase
the solubility and dissolution
rate of poorly soluble drug. Spherical agglomeration
process improves the flowability and
compressibility of drug. Spherical agglomeration is
multiple unit process in which crystallization,
agglomeration and spheronization can be carried out
simultaneously. Formulated crystals can be
called as spherical agglomerates. Spherical
crystallization technique has been successfully utilized for
improving of flowability and compressibility of drug.
This technique may enable crystalline forms of a
drug to be converted into different polymeric form
having better bioavailability. Design layout for 22
factorial
designs design is applied to prepare different batches from F1 to F4 with
appropriate
quantity. Solvent change method is applied for the
crystallization process were speed of rotation was
adjusted as per the design layout. The particles
further evaluated with different parameters. SEM of
standard batch was evaluated with size of particle. At
last it was found that spherical agglomeration is
one of the technique through which we can design the
particle with shape, we can increase solubility
of drug as well as dissolution and we can prepare
different sized particles also.
Author
(s) Details
Swapnil Shankar Patil
Department of Pharmaceutics, Annasaheb Dange College of B. Pharmacy,
Ashta, Tal–Walwa, Sangli-416 301, Maharashtra, India.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/222
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