Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue: Advanced Study | Chapter 4 | Innovations in Medicine and Medical Research Vol. 4

 Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate

into multiple cell types and undergo robust clonal self-renewal, therefore they are considered as a
highly promising stem cell population for the tissue engineering. MSCs are identified in various adult
organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue
that surrounds the tooth root. PDL also contains MSCs population and many researchers have
isolated them and performed their detailed characterization. Here, we review the current
understanding of the features and functions of MSCs population in PDL tissues and discuss their
possibility for the application of PDL regeneration.

Author(s) Details

Atsushi Tomokiyo
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.

Shinichiro Yoshida
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.

Sayuri Hamano

Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan and OBT Research Center, Kyushu University, Fukuoka, Japan.

Daigaku Hasegawa
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.

Hideki Sugii
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.

Hidefumi Maeda
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan and Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

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