miR-221/222 in Tumor and Their Underlying Mechanism

 MicroRNA-221/222 (miRNA-221/222, miR-221/222) is non-coding microRNA which widely distributed

in eukaryotic organisms, and deeply involved in the post-transcriptional regulation of gene
expressions. According to recent studies, abnormal expressions of miR-221/222 are closely related to
the occurrence and development of various kinds of malignant tumors. The role of miR-221/222 in
tumor development and their potential molecular mechanism in various cancers, including liver
cancer, colorectal cancer, cervical cancer, ovarian cancer, and endometrial carcinoma etc, are
summarized and reviewed in this paper. Moreover, the potential translational biomarker role of
abnormal miR-221/222 level in tumor or blood circulation for tumor diagnosis is also discussed.

Author(s) Details

Xin Cao
Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Qian Song
Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Xiaoling Lu,
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.

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