Using a variety of hydroxypropyl methylcellulose grades, the current study analyses the effect of a multimodal dissolving profile on the drug release of zidovudine-containing sustained-release hydrophilic matrices. Zidovudine is commonly used to treat AIDS, either alone or in combination with other antiviral medications. It was the first anti-HIV treatment to earn FDA approval for clinical usage. Matrixes were constructed using a combination of multiple grades of HPMC, including HPMCK4M and HPMCK15M, to maintain the medication's release. In order to imitate the in-vivo condition, in-vitro multimodal dissolution investigations were conducted. The drug's exposure from the stomach to the intestine/colon determines the pH/buffer. pH fluctuations have an effect on drug breakdown and release for absorption, according to the study. Matrices also allow for a very controlled delivery of the medication zidovudine over a long period of time.
Author(S) Details
Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, 452001, India.
View Book:- https://stm.bookpi.org/CACS-V6/article/view/4347
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