The human heat shock protein is made up of eight homologous chaperones: six in the reticulum and mitochondria, and two in the cytosol and nucleus. These proteins express differently in different tissues, hinting that they serve different biological activities. The levels of salivary Heat shock protein 70 in healthy people are compared to those in radiation patients in this study. Materials and Methods: The experimental group consisted of 40 people with head and neck cancer who were referred to the department of oncology for radiotherapy and were compared to 40 healthy people. Saliva and serum samples were collected and Heat shock protein 70 levels were determined using the ELIZA (enzyme linked immunoassay for HSP 70) method, with statistical analysis using the independent student 't' test. It was determined that P0.05 was statistically significant. In compared to the control group (3.170 ng/ml), there was a substantial rise in Serum Heat Shock Protein 70 levels in the Experimental group (6.525 ng/ml). Salivary HSP70 levels were significantly higher in the experimental group (5.694 ng/dl) than in the control group (2.641 ng/dl). Conclusion: Salivary and serum Heat shock protein 70 levels increased significantly in people receiving radiation for head and neck cancer, indicating that it is an effective cell stress marker.
Author (S) Details
Mithra N. Hedge
Department of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, Deralkatte, Nitte University, Mangalore, India.
Nireeksha Shetty
Department of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, Deralkatte, Nitte University, Mangalore, India.
N. Suchetha Kumari
Department of Biochemistry, K. S. Hegde Medical Academy, Deralkatte, Nitte University, Mangalore, India.
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