The study looked at existing data on quinine pharmacokinetics in children, pregnant women, and the elderly, identified factors that influence quinine pharmacokinetics, and looked at the relationship between quinine pharmacokinetics and treatment outcomes (therapeutic and safety) for various dosage regimens.
Web of Sciences, Cochrane Library, Scopus, and
PubMed were the databases utilised in this systematic search for relevant
research papers published up to October 2020 using the given search parameters.
Quinine pharmacokinetics were found to be impacted by the severity of illness,
administration methods, and nutritional status in these susceptible
individuals. The recommended doses for both simple and severe malaria are often
sufficient for the elderly and children with uncomplicated malaria. Dose
changes may be essential in pregnant women with both simple and severe malaria,
as well as children with complex malaria. In these vulnerable patient groups,
pharmacokinetic studies with large sample numbers and a revision of the MIC
(minimum inhibitory concentration) should be considered.
Teerachat Saeheng,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College, Thammasat University, Rangsit Campus, 99 Moo 18 Phaholyothin Road, Klong Luang District, Pathumthani 12121, Thailand.
Kesara Na-Bangchang,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College, Thammasat University, Rangsit Campus, 99 Moo 18 Phaholyothin Road, Klong Luang District, Pathumthani 12121, Thailand and Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Thailand.
Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6951
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