The need of
developing novel techniques to refractive modelling of the cornea using laser
radiation is undeniable from a scientific and practical standpoint.
The goal of this
research is to create novel refractive modelling methods for the cornea based
on riboflavin saturation and exposure to radiation from an argon-fluorine
excimer laser.
The researchers
looked at experimental (20 porcine eyes, 90 rabbit eyes) and clinical
investigations on photorefractive and phototherapeutic surgeries with
riboflavin saturation of the corneal stroma (610 operations). A "Microscan
Visum-500" excimer laser was used to make a rapid shift to energy
densities below the ablation threshold without the need for additional
calibrations (Optosystems, Russia). After riboflavin saturation, the advantages
of refractive keratomodeling using an argon-fluorine excimer laser in ablative
and subablative modes. In both experimental and clinical experiments, the
stroma has been shown to be beneficial. Isotonic 0.25 percent riboflavin
solution had no influence on the accuracy of refractive ablation and also
reduced the harmful effects of produced secondary radiation on keratocytes and
nerves. As a result, both the aseptic inflammatory response and the risk of
developing permanent fibroplasia were lowered. Ablation with riboflavin
resulted in a damped crosslinking reaction, which enhanced the photoprotective
and strength properties of the thinned cornea. A refractive keratomodeling
effect was identified when energy densities were provided below the stromal
ablation threshold. The overall radiation dosage as well as the geography of
the afflicted region dictated the size of this refractive impact. This
technology allows for laser-induced refractive keratomodeling without the need
for corneal ablation. After riboflavin saturation, refractive
modelling of the cornea with an argon-fluorine excimer laser in ablative and
subablative modes opens up new possibilities for laser ametropia correction.
Author(S) Details
I. M. Kornilovskiy
National Medical and
Surgical Center Named after N. I. Pirogov, Ministry of Health of Russia,
Moscow, Russia.
View Book:- https://stm.bookpi.org/NHMMR-V10/article/view/6963
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