Synthesis of New Isolated Pyrazolo, Isoxazolo Derivatives Incorporating Pyrido[1,2]thiazinoquinoline: Advanced Study | Chapter 1 | Current Advances in Chemistry and Biochemistry Vol. 5

 2,9-diacetyl-7,14-diamino-5,5a,6a,7,12,12a-hexahydro-[1,2]thiazino[4',5':5,6]pyrido[2,3-g] 2,9-diacetyl-7,14-diamino-5,5a,6a,7,12,12a-hexahydro-[1,2]thiazin [5,4-b]thiazino[1,2]thiazino[1,2]thiazino[1,2]thiazino[ Treatment of,14-diamino-5,5a,12,12a-tetrahydro-[1,2]thiazino[4',5':5,6] with quinoline-1,6,8,13(2H,4H,9H,11H)-tetraone(2) yielded quinoline-1,6,8,13(2H,4H,9H,11H)-tetraone(2). [2,3-g]pyrido[2,3-g]pyrido[2,3-g]pyrid 1,2 thiazino[5,4-b]quinoline-1,6,8,13 thiazino[5,4-b]quinoline-1,6,8,13 thiazino[5,4-b]quinoline (2H,4H,9H,11H) -tetraone (1) with glacial acetic acid and acetic anhydride Arylide derivatives are produced by reacting thiazino quinoline (2) with aromatic aldehydes (3a-c) and a piperdine catalyst ( 4a-c).

The reaction of arylidene derivatives (4a-c) with an equimolar amount of hydrazine hydrate and/or phenylhydrazine in a base catalyst yielded N-acetylpyrazolo derivatives (5a-c) and N-phenylpyrazolo derivatives (6a-c). The corresponding isooxazolo pyrimidine derivatives can also be obtained by reacting arylidene derivatives (4a-c) with an equimolar quantity of hydroxylamine hydrochloride in ethanol in the presence of sodium hydroxide as a catalyst (7a-c). Spectroscopic examination (IR, 1H-NMR, 13CNMR, and MS) and elemental analysis were used to determine the structure of the produced compounds.

Author(s) Details

Nadia A. A. Elkanzi
Chemistry Department, College of Science, Jouf University, P.O.Box: 2014, Sakaka, Saudi Arabia and Chemistry Department, College of Science, Aswan University, Aswan, 81528, Egypt.

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