The hunt for plant-based remedies for atopic dermatitis (AD), a recurrent dermatological disorder with a high prevalence in tropical areas, has always piqued interest. Oroxylum indicum Linn (Bignoniaceae) is a commonly used medicinal plant that has not yet been scientifically proven to be useful in the treatment of Alzheimer's disease. The goal of this study was to see if an ethyl acetate extract from the bark of Oroxylum indicum could help with Alzheimer's disease. The plant, sometimes known as midnight terror or Indian trumpet flower plant, is found all over Southeast Asia. The dorsal skin of 2,4-dinitrochlorobenzene-sensitized BALB/C mice was topically administered once a day for 6 weeks with five cream formulations containing Oroxylum indicum ethyl acetate bark extract in varying concentrations (0 percent, 1.25 percent, 2.5 percent, 3.75 percent, and 5 percent). The negative and positive controls were Phosphate-Buffered Saline (PBS) and Protopic (Tacrolimus 0.1 percent). All mice were evaluated for AD-like symptoms, such as the appearance of eczematous skin lesions, the degree of pruritus, and histological changes.
Results: In immunized mice, the plant extract at 5% suppressed dermatitis scores by 23.26 percent (n=6, p0.001) and scratching frequency by 34.86 percent (n=6, p0.001) compared to the negative control, while also significantly reducing signs of parakeratosis, hyperplasia, spongiosis, acanthosis, as well as epidermal and dermal thickness.
Conclusion: These findings validated Oroxylum indicum's 5-percent inhibitory effect on the progression of Alzheimer's disease when added into a cream formulation and highlighted the plant's medicinal potential in disease therapy. However, more research into the immunosuppressive mechanism of the drug is needed. The interplay of key phytocomponents and the extract should ultimately facilitate the use of this excellent medicinal plant.Author (s) Details
Do Hoang Thu Trang
Department of Biochemistry, School of Biotechnology, International University - Vietnam National University Ho Chi Minh City, HCMC, Vietnam.
Hoang Le Son
Department of Biochemistry, School of Biotechnology, International University - Vietnam National University Ho Chi Minh City, HCMC, Vietnam.
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