Scientists have been trying to figure out how to speed up the proliferation of endothelial cells (EC) in vascular biomaterials and devices so that they can repair, regenerate, or build an endothelial monolayer as quickly as feasible. By directly encouraging EC growth on the surface while suppressing smooth muscle cells (SMC) and macrophages, a variety of approaches have been devised to achieve this goal. However, a 2017 discovery that the endothelium monolayer in regenerated tissues does not come into touch with implanted biomaterials provided us with new inspiration, and offered the idea of "spatiotemporal orderliness of function" to describe macrophage actions. This objective phenomena and law should be followed by SMC and EC on implanted biomaterials in time and space, as well as the functionalities endowed for the implants' surfaces. In the following research, we discovered a series of new mysteries of EC growth, much to our amazement. These minor subtleties, which are often overlooked in scientific research, have the potential to provide new guidelines for universal mature cell proliferation, in addition to explaining the causes for varied blood implantation failures.
Author(s) DetailsJingan Li
School of Materials Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China.
Yachen Hou
School of Materials Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China.
Kun Zhang
School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China.
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