The absorbance method and the area under the curve method were used to develop and validate the loperamide hydrochloride tablet method of analysis. The optimum solvent in this study was 0.1 N methanol and hydrochloric acid (9:1), with maximum absorption at wavelength 259.00 nm.
The linearity of loperamide hydrochloride was determined in the concentration range 200-600 ppm using the absorbance method and the areas under the curve method, with correlation coefficient values of 0.9998 and 0.9865, respectively. The findings revealed that loperamide hydrochloride levels in The absorbance method and the area under the curve method yielded 105.71 percent and 96.20 percent generic pills, respectively. The findings of the absorbance method and the area under the curve method for determining loperamide levels in trademark pills were 102.85 percent and 98.57 percent, respectively. Both samples met the requirements of Pharmacopoeia Indonesia edition V, which are 90% to 110 percent. The absorbance method for the analysis of loperamide hydrochloride in tablets is legitimate, however the area under the curve technique is unsuitable for the analysis of loperamide hydrochloride in tablets.Author (s) Details
Harrizul Rivai
Faculty of Pharmacy, Andalas University, Indonesia.
Renny Puspita
School of Pharmaceutical Science, Kurao, Indonesia.
Sesry Misfadhila
School of Pharmaceutical Science, Kurao, Indonesia.
View Book : - https://stm.bookpi.org/TIPR-V3/article/view/1149
No comments:
Post a Comment