A precise, reliable, rapid, and inexpensive simple approach for the analysis of bisacodyl tablets has been devised and validated using UV spectrophotometry with absorbance technique and area under the curve. This process is carried out in a 0.1 N hydrochloric acid solvent at a maximal absorption wavelength of 263.60 nm and a region under the curve of 244.40 - 297.60 nm. The analytic procedure is validated using linearity, identification limits, quantification limits, precision, and accuracy. The regression equation y=0.02156x + 0.09258 (r=0.99963) shows the linearity of the absorbance method under the curve, while the regression equation y=0.30618x + 1.17400 (r=0.99787) shows the linearity of the broad area method. The detection and quantification limits for the absorbance method are 1.411099 and 4.276059, respectively, while the detection and quantification limits for the region under the curve method are 1.968774 and 5.9659197, respectively. The absorbance approach's region under the curve and accuracy also meet the validation standards of 80-120 percent. The absorbance method's region under the curve and precision satisfied the established criteria. criteria with an RSD of less than 2%. To conduct statistical analysis, the paired sample t test was utilized, and the findings revealed that the two The approaches were not that dissimilar. Bisacodyl can be measured using both the absorbance method and the small area method. The curves indicate the results of the analysis.
Author (s) DetailsHarrizul Rivai
Faculty of Pharmacy, Andalas University, Limau Manih Campus, Padang 25163, Indonesia.
Nia Pratama
College of Pharmaceutical Science, Jl. Tamansiswa No. 9, Padang 25138, Indonesia.
Ridho Asra
College of Pharmaceutical Science, Jl. Tamansiswa No. 9, Padang 25138, Indonesia.
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