Obesity is a medical condition marked by an excess accumulation of body fat and the metabolic syndrome that results. Modulation of metabolic pathways is important in the pathogenesis of many diseases, including obesity. By examining the levels of tumour markers and cortisol (a stress-induced hormone) in obese people, we were able to establish a link between obesity, metabolic stress, and tumour. Thirty-three obese (18 males, 15 females, BMI=34 3.8 Kg/M2) and 37 apparently non-obese (19 males, 18 females, BMI=22 1.4 Kg/M2) people (controls) volunteered to take part in this study. All of the participants were drug-free (i.e., no alcohol, cigarettes, or steroids) and appeared to be healthy adults with no medical issues. Before being accepted into the study, each participant's body weight and height were measured, and the BMI was calculated. Obesity was defined using the body mass index (BMI; Kg/M2), with a BMI greater than 25 Kg/M2 indicating overweight and a BMI greater than 30 Kg/M2 indicating obesity. Using enzyme linked immunosorbent assay methods, the plasma levels of carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), and cortisol were determined in these subjects. When compared to controls, plasma levels of CA125 and cortisol increased significantly (p0.05), but plasma levels of CEA and AFP did not change significantly (p>0.05). The increased rate of cortisol and CA125 synthesis in obesity could be due to metabolic changes.
Author(s) DetailsMoses O. Akiibinu
Department of Biochemistry and Chemistry, Caleb University Lagos, Nigeria.
Bob O. Soile
Department of Biochemistry and Chemistry, Caleb University Lagos, Nigeria.
Ajibola M. U. Amzat
Department of Biochemistry and Chemistry, Caleb University Lagos, Nigeria.
Oyetunji T. Kolawole
Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
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