Aims: Chloroquine is a member of the 4-aminoquinoline medication class that is used to prevent and cure malaria in locations where the disease is known to be susceptible to its effects. Metals can form covalent bonds with carbon in most cases, resulting in metal-organic complexes. Our goal is to synthesize the chloroquine–titanium complex and investigate how it coordinates. Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019. Place and Duration of Study:
Methodology: The chloroquine Ti(II) complex was created by reacting chloroquine phosphate with titanium(IV) oxide. UV, IR, and 1H NMR spectroscopy were used to characterize the metal complex.The complex's UV spectra revealed intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and the d-d transition. The complex's IR spectra revealed the involvement of the amine and imine groups in collaboration with Ti. Chloroquine acted as a bidentate ligand as a result of this. The amine group's role in coordination was further demonstrated by 1H NMR of the spectrum.
Conclusion: Chloroquine's ability to sequester the Ti (II) ion has been demonstrated. This medication can remove Ti ions from a solution, the environment, or a biological system.
Author (s) Details
I. E. Otuokere
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.
K. C. Amadi
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.
C. O. Alisa
Department of Chemistry, Federal University
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