G-Quadruplex and Ligand Interactions | Chapter 23 | Socio-Scientific Interaction in Diabetes and Cancer and Its Management

 Designing ligands to interact with G-quadruplex (G4) of DNA is challenging due to the complexity of G4 structures and the lack of efficient experimental methods to characterize G4/ligand interactions. Existing methods can be categorized into structure-based (e.g., CD, NMR, X-ray crystallography), affinity-based (e.g., SPR, ITC, MS), and high-throughput (e.g., FRET, G4-FID, affinity chromatography, microarrays) approaches, each with its own advantages and disadvantages. High-throughput methods are emerging as a promising alternative to traditional methods for screening and designing new G4 ligands, as they are faster and more cost-effective.

G4s are found in both DNA and RNA and play an important role in a variety of physiological processes, including cancer and neurological disorders. Targeting G4s with ligands is a promising therapeutic strategy for these diseases. A significant number of G4 ligands have been developed and investigated, and most of them are deposited in the G4 Ligands Database 2.1 (http://www.g4ldb.com/).

Author(s) Details:

Patnaik Amit,
Department of Biotechnology, NIST Institute of Science and Technology Autonomous, Institute Park, Pallur Hills, Berhampur, Odisha – 761008, India.

Sinha Anita,
Biotechnology, University Department of Botany, Ranchi University Ranchi, Jharkhand-834008, India.

Oraon Vinay,
Biotechnology, University Department of Botany, Ranchi University Ranchi, Jharkhand-834008, India.

Sahu Duryodhan,
Department of Chemistry, NIST Institute of Science and Technology Autonomous, Institute Park, Pallur Hills, Berhampur, Odisha – 761008, India.

Please see the link here: https://stm.bookpi.org/SSIDCIM/article/view/12741

Synthesis and Characterization of Cu(I) and Cu(II) Complexes Formed Through Carbon Disulfide Insertion | Chapter 14 | Current Advances in Chemistry and Biochemistry Vol. 6

 Two copper complexes [(PPh3)2Cu(S2COC2H5)] (A) and [(C3H4N2)2Cu(S2COC2H5)] (B) have been synthesized by the insertion of CS2 in (PPh3)2CuCl2 and (C3H4N2)2CuCl2, respectively in mixed At room temperature, a solvent of dichloromethane and ethanol. FTIR and ESR spectroscopy were used to characterize the complexes. Both complexes were discovered to be air-stable and to have distorted square planar geometry.

Author (S) Details

Samim Sultana
Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India.

Prof. Pradip. K. Gogoi
Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India.

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4-N-(7-Chloroquinolin-4-yl)-1-N,1-N-diethyl petane- 1,4-diamine Ti Complex: Synthesis and Characterization | Chapter 16 | Technological Innovation in Pharmaceutical Research Vol. 3

 Aims: Chloroquine is a member of the 4-aminoquinoline medication class that is used to prevent and cure malaria in locations where the disease is known to be susceptible to its effects. Metals can form covalent bonds with carbon in most cases, resulting in metal-organic complexes. Our goal is to synthesize the chloroquine–titanium complex and investigate how it coordinates. Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019. Place and Duration of Study:

Methodology: The chloroquine Ti(II) complex was created by reacting chloroquine phosphate with titanium(IV) oxide. UV, IR, and 1H NMR spectroscopy were used to characterize the metal complex.
The complex's UV spectra revealed intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and the d-d transition. The complex's IR spectra revealed the involvement of the amine and imine groups in collaboration with Ti. Chloroquine acted as a bidentate ligand as a result of this. The amine group's role in coordination was further demonstrated by 1H NMR of the spectrum.

Conclusion: Chloroquine's ability to sequester the Ti (II) ion has been demonstrated. This medication can remove Ti ions from a solution, the environment, or a biological system.

Author (s) Details

I. E. Otuokere
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.

K. C. Amadi
Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.

C. O. Alisa
Department of Chemistry, Federal University

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