Study of Morphology of Large Intestine in 50 Donated Embalmed Cadavers | Chapter 5 | Current Progress in Medicine and Medical Research Vol. 9

Aim: To study the study of plants of large entrails to document the presence of some growth or bulge.Material and Methods: A study was transported in the Department of Anatomy of K. J. Somaiya Medical College in which 50 big intestines from gave embalmed cadavers were examined for the presence of some growth or bulge.Results: In 5 cadavers a hard bulge was noticed in the distal part of downward colon. On incising, a mass was noticed in its posterior obstruction. It measured 5cm x 5cm circumscribing nearly half the lumen but not appearance any signs of impediment. Histopathology confirmed the disease of adenocarcinoma.Clinical Significance: Colon Carcinoma involves historical factors, environmental uncoverings, dietary tendencies, and inflammatory environments of the gastrointestinal tract. Death from colon malignancy usually results from metastases in the liver.  Conclusions: As colon tumor is the most coarse carcinoma accompanying high death rates, the cure is greater when the affliction is detected at inception. Early detection and screening is of excellent importance. Colonoscopy detects few colon polyps and cancers early enough that they may be doctored.

Author(s) Details:

SharadKumar Pralhad Sawant,
Department of Anatomy, K. J. Somaiya Medical College and Research Centre, Maharashtra University of Health Sciences, MUHS, India.

Shaheen Rizvi,
Department of Anatomy, K. J. Somaiya Medical College and Research Centre, Maharashtra University of Health Sciences, MUHS, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11689

A Review on Minimally Invasive Right Colectomy from Conventional Laparoscopic Resection to Robotic-Assisted Surgery | Chapter 1 | Recent Developments in Medicine and Medical Research Vol. 12

 The goal of robotic-assisted abdominal surgery was to overcome the limitations of the traditional laparoscopic technique. The current narrative review compares the short and long-term results, costs, and learning curve of laparoscopic versus robotic-assisted techniques for right colectomy (RC). The main technical issues of using robotic assistance for this treatment are explored in further detail. The introduction of next-generation optics (3D, 4K) and more ergonomic instruments can be seen as a step forward in terms of technical facilitation. Because of the unique vascular structure of the right and middle colics, minimally invasive RC is considered technically tough. Due to the high prices and operating times, robotic RC has failed to gain traction. Its use, on the other hand, may have advantages in terms of short-term clinical outcomes and facilitates the acquisition of basic surgical skills, thus shortening the learning curve of minimally invasive colorectal surgery.

Author(S) Details

Dilip M. Chafle
Research Centre of Taywade College, Koradi, Dist. Nagpur (441111), India.

Carmen Payá-Llorente
Department of General and Digestive Surgery, Hospital Universitario Doctor Peset, Valencia, Spain.

Lelde Lauka
Department of Digestive and Hepatobiliary Surgery, Henri-Mondor Hospital, University Paris Est-Créteil – UPEC, Créteil, 94010, France.

Elisa Reitano
Department of Digestive and Hepatobiliary Surgery, Henri-Mondor Hospital, University Paris Est-Créteil – UPEC, Créteil, 94010, France.

Riccardo Memeo
Department of Emergency and Organ Transplantation, University Aldo Moro of Bari, Bari, Italy.

Paschalis Gavriilidis
Department of Hepato-Biliary-Pancreatic and Oesophago-Gastric Surgery, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W12 0HS, UK.

Francesco Brunetti
Department of Digestive and Hepatobiliary Surgery, Henri-Mondor Hospital, University Paris Est-Créteil – UPEC, Créteil, 94010, France.

Aleix Martínez-Pérez
Department of General and Digestive Surgery, Hospital Universitario Doctor Peset, Valencia, Spain.

View Book:- https://stm.bookpi.org/RDMMR-V12/article/view/4667

Age-Specific Features of the Enzymatic Proliferation Markers upon the Cancer of Different Localisations | Chapter 9 | Highlights on Medicine and Medical Research Vol. 10

 The enzyme activity features of thymidilate "salvage route" synthesis and adenosine catabolism in blood serum and cancer tissues from solid nearby tumours of various localizations were compared. The goal of this study was to look at the diagnostic value of thymidilate metabolism enzymes and adenosine deaminase (ADA) activity, as well as their relationship to tumour growth. Methods: The radioisotope technique and spectrophotometry were used to determine enzyme activity in 169 patients' blood serum and lymphocytes. The activity of thymidine phosphorylase in blood serum is lower in cancer patients than in healthy people, according to the findings. It was accompanied by an increase in the activities of thymidine kinase (TK) and adenosine deaminase (ADA). The characteristics of enzyme activity were shown to be related to age and illness stage. The activity of enzymes changed depending on the success of chemotherapy and tumour elimination. The ADA activity properties of lymphocytes can be a useful indicator of their malfunction. Conclusion: Our findings imply that studying individual enzyme activity dynamics in blood serum could be useful for illness recurrence detection and drug treatment optimization.

Author(s) Details

Berta G. Borzenko
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.

Elena M. Bakurova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.

Kseniia A. Mironova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.

Ulia D. Tursunova
Department of Biochemistry, Maxim Gorky Donetsk National Medical University, Donetsk, Ukraine.

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Targeting of Cancer Cell Drug Resistance Phenotype and Metastasis with Xanthium strumarium L. Extract | Chapter 8 | Trends in Pharmaceutical Research and Development Vol.3

The antiproliferative activity of Xanthium strumarium L. extract (XFC), a traditional herbal medicine, is
believed to alter the cell mitotic machinery, but the molecular mechanisms underlying its anticancer
actions remain poorly characterized. We found that XFC exerted significant in vitro cell proliferation
inhibitory effect against the ovarian, breast, and colon cancer cell line models tested. In vitro, XFC
efficiently targeted both the cytotoxic drug chemoresistance phenotype of SKOV-3 and ES-2 ovarian
cancer cells. Early apoptosis and late apoptosis were effectively induced by XFC extract in ES-2 cells,
whereas late apoptosis and necrosis events were triggered in SKOV-3 cells. Cell cycling regulation
was trapped by XFC extract in the G2/M phase in both the ES-2 and SKOV-3 cell models. This effect
was, in part, attributable to increased dose-dependent tubulin polymerization, which was increased in
SKOV-3 cells. Whereas XFC extract triggered poly (ADP-Ribose) polymerase (PARP) cleavage in
both ES-2 and SKOV-3 cells, it only lowered Nrf2 in ES-2 cells and phosphorylated Akt levels in
SKOV-3 cells. Interestingly, cell cycling regulators Cdk4, Cyclin D3, and p27 were all decreased in
SKOV-3 cells. XFC extracts were effective in inhibiting in vitro migration in both ovarian cancer cell
models. In addition, we found promising in vivo results when XFC exhibited significant antimetastatic
action in a mouse model of colon cancer. Such in vitro and in vivo evidence confirm that XFC has
excellent anti-tumor activity, and represents a potential promising source of anticancer agents in the
targeting of the chemoresistance phenotype and of metastasis in human ovarian and colon cancers.

Author(s) Details

Marbelis Francisco Fernandez,
Laboratoire d’Oncologie Moléculaire, Département de Chimie, Centre d’Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois, Université du Québec à Montréal, Montreal, Quebec, Canada.

Janet Piloto-Ferrer
Departamento de GeneticaToxicologica, Centro de Investigacion y Desarrollo de Medicamentos (CIDEM), Avenida 26, No. 1605 e/Puentes Grandes y Boyeros, La Habana, Cuba.

Borhane Annabi
Laboratoire d’Oncologie Moléculaire, Département de Chimie, Centre d’Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois, Université du Québec à Montréal, Montreal, Quebec, Canada.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/222