Study of Morphology of Large Intestine in 50 Donated Embalmed Cadavers | Chapter 5 | Current Progress in Medicine and Medical Research Vol. 9

Aim: To study the study of plants of large entrails to document the presence of some growth or bulge.Material and Methods: A study was transported in the Department of Anatomy of K. J. Somaiya Medical College in which 50 big intestines from gave embalmed cadavers were examined for the presence of some growth or bulge.Results: In 5 cadavers a hard bulge was noticed in the distal part of downward colon. On incising, a mass was noticed in its posterior obstruction. It measured 5cm x 5cm circumscribing nearly half the lumen but not appearance any signs of impediment. Histopathology confirmed the disease of adenocarcinoma.Clinical Significance: Colon Carcinoma involves historical factors, environmental uncoverings, dietary tendencies, and inflammatory environments of the gastrointestinal tract. Death from colon malignancy usually results from metastases in the liver.  Conclusions: As colon tumor is the most coarse carcinoma accompanying high death rates, the cure is greater when the affliction is detected at inception. Early detection and screening is of excellent importance. Colonoscopy detects few colon polyps and cancers early enough that they may be doctored.

Author(s) Details:

SharadKumar Pralhad Sawant,
Department of Anatomy, K. J. Somaiya Medical College and Research Centre, Maharashtra University of Health Sciences, MUHS, India.

Shaheen Rizvi,
Department of Anatomy, K. J. Somaiya Medical College and Research Centre, Maharashtra University of Health Sciences, MUHS, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11689

Determination of Histopathological Spectrum of Male Genital System Tumours in a Tertiary Care Hospital Faridkot, Punjab, India| Chapter 5 | Perspective of Recent Advances in Medical Research Vol. 1

 The male genital system consists of prostate, seminal vesicle, testes, epididymis, vas deferens, bulbourethral gland, ejaculatory duct, penis and scrotum. Male genital cancers are histologically diverse. They are difficult to detect and treat because of their anatomic locations, biological characteristics and complications. To study the histopathological spectrum of tumours of the male genital system according to World Health Organisation (WHO) classification. The present study is a hospital-based descriptive study conducted in the Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India, from February 2019 to August 2020, included 128 cases. All biopsies, specimens and blocks for review and slides of male genital tract tumours were processed and slide stained with Haematoxylin and Eosin (H&E) stain. Also used were serum tumour markers and immunohistochemical stains. The clinical information from the requisition form related to the male genital system, histopathological findings and diagnosis were recorded on the predesigned proforma. The association between categorical variables was determined using Pearson’s Chi-square test. A p-value <0.05 was considered statistically significant for this study. The present study included 128 cases, of which the majority of the cases 82 (64%) were that of the prostate, 28 case (21.9%) of the penis, 15 case (11.7%) of testes, 2 case (1.6%) were that of the scrotum and 1 case (0.8%) was of the epididymis. Prostate tumours outnumbered all other tumours of the male genital tract comprising adenocarcinoma of the prostate followed by squamous cell carcinoma of the penis and mixed Germ Cell Tumour (GCT) of the testes. The present study provides updated information regarding the histopathological spectrum of male genital system tumours.

Author(s) Details:

Aradhana Singh Hada,
Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab Medical Council, Punjab, India.

Sarita Nibhoria,
Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab Medical Council, Punjab, India.

Vaneet Kaur Sandhu,
Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab Medical Council, Punjab, India.

Nitin Nagpal,
Department of Surgery, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Please see the link here: https://stm.bookpi.org/PRAMR-V1/article/view/9000

A Case Report on Primary Adenocarcinoma of Jejunum | Chapter 9 | New Frontiers in Medicine and Medical Research Vol. 10

 The malignancy of the small intestine is a fairly uncommon condition. The most common site for intestinal cancer is the duodenum. The stricture is the most common symptom of the lesions. In India, tuberculosis is the most common cause of small intestinal stricture. Small intestinal obstruction is caused by a small fraction of tumours. Endoscopy is relatively inaccessible to small intestinal strictures distal to the duodenum. This makes a definite preoperative diagnosis difficult. The signs of jejunal cancer are quite generic, and diagnosis requires a high index of suspicion. The goal of this case report is to highlight a case of primary adenocarcinoma of the jejunum that had a favourable prognosis following surgical resection.

Author (S) Details

Vaneeta Bhardwar
Department of Pathology, PIMS, Jalandhar – 144006, Punjab, India.

Neha Batra
Department of Pathology, PIMS, Jalandhar – 144006, Punjab, India.

Subhash Goyal
Department of Surgery, PIMS, Jalandhar – 144006, Punjab, India.

Kanwal Masih
Department of Pathology, PIMS, Jalandhar – 144006, Punjab, India.

View Book :- https://stm.bookpi.org/NFMMR-V10/article/view/3508

Study on Simulators of Pancreatic Adenocarcinoma: An Approach to Avoid Misdiagnosis | Chapter 6 | Highlights on Medicine and Medical Science Vol. 8

 Examinable neoplastic, inflammatory, and benign pancreatic as well as non-pancreatic processes that can mimic pancreatic adenocarcinoma will be shown. Pancreatic adenocarcinoma (PA) is one of the most aggressive cancers, accounting for the fourth highest number of cancer-related fatalities in the Western world. When compared to normal pancreatic tissue modelling PA, focal fatty infiltration is usually most evident in the head of the pancreas, and contrast enhancement on CT usually shows as a region with reduced contrast matherial amplification. In most cases, imaging of a hypoathenuating lesion in the head of the pancreas indicates cancer. However, radiologists must exercise caution because a false positive diagnosis can result in unneeded surgery, which can be dangerous.

Author (s) Details

Atanas Dimitrov Hilendarov
Department of Diagnostic Imaging, Faculti of Medicine, Medical University, Plovdiv, Bulgaria.

Alexandar Asenov Georgiev
Department of Diagnostic Imaging, Faculti of Medicine, Medical University, Plovdiv, Bulgaria.

Lyubomir Georgiev Chervenkov
Department of Diagnostic Imaging, Faculti of Medicine, Medical University, Plovdiv, Bulgaria.

View Book :- https://stm.bookpi.org/HMMS-V8/article/view/2166

A Current and Evolving Treatment Landscape on Esophageal Cancer | Chapter 16 | Highlights on Medicine and Medical Research Vol. 10

 Overall survival for patients with many types of tumours has improved thanks to developments in cutting-edge technology, trendy diagnostic and prognostic molecular markers, and cutting-edge surgical procedures. However, there is a gap between esophageal cancer and the rapid advancements in cancer treatment found in other cancers. The 5-year survival rate for patients with esophageal cancer is just 19.9%, according to statistics from the Surveillance, Epidemiology, and End Results Program (SEER) [1]. Poor prognosis is most likely attributable to an overabundance of patients with advanced disease at the time of diagnosis, as well as the disappointing results of present treatments. The epidemiology and recently revised staging of esophageal and esophagogastric junction tumours will be discussed in this article. Endoscopic resection, surgery, radiation therapy, and systemic therapy will be discussed individually and as components of multimodality treatment. We'll go over how targeted therapy and immunotherapy have changed the treatment environment. Clinical research is shifting away from classic empiric chemotherapy and toward more customised treatments based on molecular oncology and immunotherapy. Further research into prognostic values may aid in determining the best treatment and management strategy for patients with esophageal cancer, with the goal of improving survival. Lessons obtained in epidemiology, molecular genetics, pharmacogenomics, and precision medicine are used to inform clinical trials examining prevention, early diagnosis, and therapy of early and advanced disease.

Author(s) Details

Nicole B. Balmaceda
University of Kansas School of Medicine, University of Kansas, 3901 Rainbow Blvd, Kansas City, Kansas 66160, USA.

Joaquina C. Baranda
Department of Hematology and Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Westwood, KS 66205, USA.

Peter DiPasco
Department of Surgery, University of Kansas, 3901 Rainbow Blvd, Kansas City, Kansas 66160, USA.

Weijing Sun
Department of Hematology and Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Westwood, KS 66205, USA.

John Ashcraft
Department of Hematology and Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Westwood, KS 66205, USA.

Joseph Valentino
Department of Hematology and Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Westwood, KS 66205, USA.

Mazin Al-Kasspooles
Department of Hematology and Medical Oncology, University of Kansas Cancer Center, 2330 Shawnee Mission Parkway, Westwood, KS 66205, USA.

View Book :- https://stm.bookpi.org/HMMR-V10/article/view/1127

Brief Overview of Clear Cell Adenocarcinoma of the Urethra: Review of the Literature | Chapter 4 | Research Trends and Challenges in Medical Science Vol. 1

Background: Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour.  Aims: To review the literature on CCAU.  Methods: Various internet databases were used.  Results/Literature Review: (i) CCAU occurs in adults and in women in the great majority of cases. (ii) It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii) It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv) It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v) CCAU is aggressive with low 5-year survival rates. (vi) There is no consensus opinion of treatment options that would improve the prognosis.  Conclusions: Few cases of CCAU have been reported. Urologists, gynecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

Author (s) Details

Anthony Kodzo-Grey Venyo
Department of Urology, North Manchester General Hospital, Delaunays Road, Manchester, UK.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/181