Background: In cases of severe coronavirus disease 2019
(COVID-19) affecting the lung, thromboembolic consequences have been described
as a major pathologic event that poses a serious risk to life. This is
supported by autopsy reports of alveolar destruction and pulmonary
intravascular microthrombi. The brand-new coronavirus (CoV) doesn't seem to
have any inherent procoagulant properties. The inflammatory reaction is most
likely what caused the coagulation abnormalities in COVID-19. Based on high
interleukin-6 levels, COVID-19 exhibits significant inflammation (IL-6). Based
on high D-dimer levels, this COVID-19-related inflammation causes coagulopathy
(DD). According to COVID-19, an endotheliopathy appears to be a factor in
microvascular thrombosis. This study's objective is to confirm the coagulation
anomalies in 100 patients with significant COVID-19 lung involvement and their
relationship to the disease's severity and prognosis.
Method: Indicators of inflammation, endothelial function,
and coagulation were measured and compared between patients with severe and
mild illness.
Results: Severe COVID-19 patients had higher levels of IL-6,
TNF-a, TF, VWF, D-dimer, TAT, and fibrinogen. We also assessed -TG levels that
were higher than the plasma levels of PF4 in patients with severe COVID-19, and
we found that platelet adhesion was increased. This is because PF4 is rapidly
removed from plasma. As compared to moderate COVID-19 patients, all severe
COVID-19 patients had shortened CT and CFT, high MCF, and low LY at 30 minutes.
Conclusions: TFPI is said to be a natural anticoagulant that
reduces coagulation and inflammation. As a result, we detected TFPI levels that
were above normal without causing the inflammation and coagulation to stop,
thereby demonstrating the clinical severity of individuals with severe
COVID-19.
Author (s) Details
Rossella Cacciola
Hemostasis/Hematology Unit, Department of
Experimental and Clinical Medicine, University of Catania-95123 Catania, Italy.
Elio Gentilini Cacciola
Policlinico “Umberto I”, Department of
Public Health and Infectious Diseases, “Sapienza “ University of Rome-00182
Rome, Italy.
Veronica Vecchio
Hemoastasi/Hematology Unit, Medical School
of Catania,University of Catania 95123 Catania, Italy.
Emma Cacciola
Hemostasis/Hematology Unit, Department of
Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University
of Catania, 95123 Catania, Italy.
View Book :- https://stm.bookpi.org/CPMS-V6/article/view/7687