Determination of Severe Acute Respiratory Distress Syndrome in a Patient with Sickle-Cell Anemia Requiring Veno-Venous Extracorporeal Membrane Oxygenation Therapy: Case Report and Review of the Literature | Chapter 5 | Perspective of Recent Advances in Medical Research Vol. 9

 A weapon-shaped haemoglobin that is less dissolved than regular haemoglobin is produced on account of a mutation in the beta globin deoxyribonucleic acid, which causes sickle container anaemia. Hemolytic anaemia and blood vessel blockage, that result in ischemia and infarcts, are the main traits of the condition. One of the most dicey forms is acute chest condition, which can lead to hurried respiratory failure and harsh hypoxia. Although conservative therapy is frequently direct, the syndrome may sometimes be resistant. In these extreme situations, extracorporeal sheath oxygenation (ECMO) support may be life-conditional.A 31-year-old man accompanying acute chest disease and severe aspiration was granted to our hospital's intensive care unit. Veno-venous ECMO help was started due to harsh acute respiratory distress disease (ARDS) and extensive hypoxemia (70%) accompanying a swift recovery in two together oxygenation and hemodynamic status. After 7 days, the patient was weaned off the ECMO and released 4 weeks later.Although ECMO cure for sickle cell anaemia subjects is uncommon and sometimes dubious, it can be life-conditional in certain refractory cases.

Author(s) Details:

Kotler Offer,
Department of Anesthesiology, Intensive Care and Pain Medicine, Meir Medical Center, Kfar Saba, Israel and Sackler School of Medicine, Tel Aviv University, Israel.

Dichtwald Sara,
Department of Anesthesiology, Intensive Care and Pain Medicine, Meir Medical Center, Kfar Saba, Israel and Sackler School of Medicine, Tel Aviv University, Israel.

Meyer Avraham,
Department of Anesthesiology, Intensive Care and Pain Medicine, Meir Medical Center, Kfar Saba, Israel and Sackler School of Medicine, Tel Aviv University, Israel.

M. Gorfil Dan,
Sackler School of Medicine, Tel Aviv University, Israel and Department of Cardiothoracic surgery, Rabin Medical Center, Petah-Tikva, Israel.

Ifrach Nisim,
Department of Anesthesiology, Intensive Care and Pain Medicine, Meir Medical Center, Kfar Saba, Israel and Sackler School of Medicine, Tel Aviv University, Israel.

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Diagnosis of Renal Function and Structure for Sickle Cell Anemia in India during Vaso-occlusive Crisis (Voc) | Chapter 10 | Current Practice in Medical Science Vol. 6

In the current investigation, four patients of sickle cell anaemia during a vaso-occlusive crisis were reported to have significant renal derangement. We decided to describe this study because there were few reports from India about renal function abnormalities in sickle cell anaemia cases during Vaso-occlusive crises. Due to the inheritance of two sickle haemoglobin genes from both parents, sickle cell disease (SCD) is one of the most prevalent severe monogenic illnesses in the world. Low haemoglobin levels, high reticulocyte and LDH levels were present in every patient. Urine testing revealed proteinuria, extra red blood cells, and hyposthenuria. High serum urea concentrations of 47 to 200 mg/dl, 0.58 to 6.2 mg/dl of creatinine, and 22 to 93 mg/dl of urea nitrogen. The abdomen in the United States usually displayed bilaterally enlarged kidneys with acute renal parenchymal alterations. The current study demonstrates that there is severe renal dysfunction during VOC in about 6.6 percent of homozygous sickle cell anaemia cases. In one of the patients, a kidney biopsy revealed cellular and fibrocellular crescents in addition to Focal and Segmental Glomerulosclerosis (FSGS). In the capillary lumina, sclerotic RBC were discovered. Twenty to thirty percent of the patients had tubular atrophy and interstitial fibrosis. Renal failure is therefore common in India during a sickle cell crisis. However, given that it is an emergency, one must take proactive action and be aware of this fact.

 

Author (s) Details

Pandey Jyotsna

Department of Laboratory Medicine, Apollo Hospitals, Bhubaneswar, Odisha, India.

Mohanty Dipika

Department of Laboratory Medicine, Apollo Hospitals, Bhubaneswar, Odisha, India.

Mohapatra Nachiketa

Department of Laboratory Medicine, Apollo Hospitals, Bhubaneswar, Odisha, India.

Das Sreeya

Department of Laboratory Medicine, Apollo Hospitals, Bhubaneswar, Odisha, India.

 

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