In the current investigation, four patients of sickle cell anaemia during a vaso-occlusive crisis were reported to have significant renal derangement. We decided to describe this study because there were few reports from India about renal function abnormalities in sickle cell anaemia cases during Vaso-occlusive crises. Due to the inheritance of two sickle haemoglobin genes from both parents, sickle cell disease (SCD) is one of the most prevalent severe monogenic illnesses in the world. Low haemoglobin levels, high reticulocyte and LDH levels were present in every patient. Urine testing revealed proteinuria, extra red blood cells, and hyposthenuria. High serum urea concentrations of 47 to 200 mg/dl, 0.58 to 6.2 mg/dl of creatinine, and 22 to 93 mg/dl of urea nitrogen. The abdomen in the United States usually displayed bilaterally enlarged kidneys with acute renal parenchymal alterations. The current study demonstrates that there is severe renal dysfunction during VOC in about 6.6 percent of homozygous sickle cell anaemia cases. In one of the patients, a kidney biopsy revealed cellular and fibrocellular crescents in addition to Focal and Segmental Glomerulosclerosis (FSGS). In the capillary lumina, sclerotic RBC were discovered. Twenty to thirty percent of the patients had tubular atrophy and interstitial fibrosis. Renal failure is therefore common in India during a sickle cell crisis. However, given that it is an emergency, one must take proactive action and be aware of this fact.
Author (s) Details
Pandey Jyotsna
Department of Laboratory Medicine, Apollo
Hospitals, Bhubaneswar, Odisha, India.
Mohanty Dipika
Department of Laboratory Medicine, Apollo
Hospitals, Bhubaneswar, Odisha, India.
Mohapatra Nachiketa
Department of Laboratory Medicine, Apollo
Hospitals, Bhubaneswar, Odisha, India.
Das Sreeya
Department of Laboratory Medicine, Apollo Hospitals,
Bhubaneswar, Odisha, India.
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