One of those plants, Calendula officinalis, has medical
value since both its leaves and flowers exhibit pharmacological activity.
However, less attention has been paid to crucial pharmacological parameters,
which can be demonstrated scientifically by reverse pharmacology. An annual
herb with Mediterranean origin called calendula officinalis is widely used as
an anti-inflammatory and for wound healing. It was thought to be interesting to
assess these qualities of the Calendula officinalis leaf extract. The ability
of gels made from methanolic extracts of Calendula officinalis Linn to treat
wounds was tested using excision wound models in albino mice. Carbopol gels
were used to generate extract formulations both separately and in combination
in an equal ratio. Excision wound models showed that the treated animals'
epithelization time and wound healing activities were significantly reduced.
The enhanced free radical scavenging ability and phytoconstituents present in
hydro alcoholic extracts, which, either alone or in combination, promote wound
healing, may be responsible for the extracts' improved wound healing activity.
Increased connective tissue synthesis, especially collagen production, is
evidence that calendula extract boosted wound healing activity. The granuloma
tissue has greatly expanded. It was shown that the increased tensile strength
and wound contraction were statistically significant.
Author(s) Details:
Priyanka Pandey,
School of Studies in Chemical and Biological Sciences, MATS
University, Raipur – 492001, Chhattisgarh, India.
Wasim Raja,
Central Laboratory Facility, Chhattisgarh Council of Science and
Technology, Raipur- 492014, Chhattisgarh, India.
Please see the link here: https://stm.bookpi.org/RABS-V4/article/view/7584
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