Preliminary Study on the Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome-Related and Other Blood Parameters in Humans | Chapter 7 | Current Advances in Chemistry and Biochemistry Vol. 4

 Except for the antitumor effect, the effects of deuterium depletion on the human body have been rarely studied, and available evidence is restricted. An increase in glucose metabolism was observed in oncological patients who also had diabetes and were treated with deuterium-depleted water (DDW), and rat experiments also proved DDW's effectiveness in lowering blood sugar levels. In this study, 30 people with pre-diabetes or diabetes were enrolled in a clinical trial. For 90 days, the patients were given 1.5 liters of water containing less deuterium (104 ppm instead of 145 ppm, equivalent to 12 mmol/L in humans). The effects were studied on fasting glucose and insulin levels, peripheral glucose disposal, and other metabolic parameters. DDW's effects on other physiological factors, such as qualitative blood count, were also studied. In 15 subjects, fasting insulin and glucose levels dropped, and insulin response to a glucose load increased, while in the other 15, the changes were the opposite. In 11 of the subjects, peripheral glucose disposal increased. Significant increases in serum HDL cholesterol and significant decreases in serum Na+ concentration were also observed in the majority of the subjects, the latter likely due to activation of a Na+/H+ antiporter by the decreased intracellular deuterium level. The findings support a potential beneficial function for DDW in glucose metabolism disorders, but they raise concerns that will need more research.

Author (s) Details

Gábor Somlyai
HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary.

Ildikó Somlyai
HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary.

István Fórizs
Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary.

György Czuppon
Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary.

András Papp
Department of Public Health, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary.

Miklós Molnár
Semmelweis University, Faculty of Medicine, Institute of Pathophysiology, 1089 Budapest, Hungary.

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