Functional Improvement in β-Islet Cells, Hepatocytes and Cardiomyocytes with Decreasing Deuterium from Low Carbohydrate Intake in a Type-II Diabetic| Chapter 17 | Recent Developments in Medicine and Medical Research Vol. 7

 With systemic deuterium depletion, a 59-year-old patient with an 18-year history of type II diabetes demonstrated significant improvements in glucose tolerance tests and improved fasting hepatic glucose production. Systemic changes in insulin and hepatic glucose production in the pancreas and liver are most likely due to deuterium, which is known to impair the efficacy of ATP synthesis nanomotors. Low-carbohydrate (keto) diets combined with deuterium-depleted water can result in deuterium depletion throughout the body.

Author(S) Details

Edwin C. Jones
Department of Veterans Affairs, Knoxville Outpatient Clinic, 8033 Ray Mears Blvd., Knoxville, TN 37919, USA.

Cortney L. Jardet
Endocrinology Consultants of East Tennessee, 1450 Dowell Springs Blvd., Suite 300, Knoxville, TN 37909, USA.

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Preliminary Study on the Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome-Related and Other Blood Parameters in Humans | Chapter 7 | Current Advances in Chemistry and Biochemistry Vol. 4

 Except for the antitumor effect, the effects of deuterium depletion on the human body have been rarely studied, and available evidence is restricted. An increase in glucose metabolism was observed in oncological patients who also had diabetes and were treated with deuterium-depleted water (DDW), and rat experiments also proved DDW's effectiveness in lowering blood sugar levels. In this study, 30 people with pre-diabetes or diabetes were enrolled in a clinical trial. For 90 days, the patients were given 1.5 liters of water containing less deuterium (104 ppm instead of 145 ppm, equivalent to 12 mmol/L in humans). The effects were studied on fasting glucose and insulin levels, peripheral glucose disposal, and other metabolic parameters. DDW's effects on other physiological factors, such as qualitative blood count, were also studied. In 15 subjects, fasting insulin and glucose levels dropped, and insulin response to a glucose load increased, while in the other 15, the changes were the opposite. In 11 of the subjects, peripheral glucose disposal increased. Significant increases in serum HDL cholesterol and significant decreases in serum Na+ concentration were also observed in the majority of the subjects, the latter likely due to activation of a Na+/H+ antiporter by the decreased intracellular deuterium level. The findings support a potential beneficial function for DDW in glucose metabolism disorders, but they raise concerns that will need more research.

Author (s) Details

Gábor Somlyai
HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary.

Ildikó Somlyai
HYD LLC for Cancer Research and Drug Development, 1118 Budapest, Hungary.

István Fórizs
Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary.

György Czuppon
Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences, 1112 Budapest, Hungary.

András Papp
Department of Public Health, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary.

Miklós Molnár
Semmelweis University, Faculty of Medicine, Institute of Pathophysiology, 1089 Budapest, Hungary.

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