The goal of the study was to create Ciprofloxacin floating in situ gel formulations with a small absorption window that are absorbed largely in the GIT's proximal portions. These formulations can be used to treat Helicobacter pylori (H. pylori) infections and urinary tract infections by prolonging the focused effect on bacteria.
Methods: Different amounts of sodium alginate, a biodegradable polymer that
creates in situ gels, and calcium carbonate, a cross-linking agent, were used
to develop in situ gel formulations. The formulations were tested for physical
appearance, pH, in vitro drug release, viscosity, in vitro floating behaviour,
in vitro gelling capability, and drug content. FTIR analysis was performed on
ciprofloxacin, excipients, and formulation optimization.
Results: All of the formulations had the ideal viscosity, making them easy to
administer and swallow. With a floating lag time of 32-70 seconds, all
formulations floated for more than 12 hours. As the polymer and gelling agent
concentrations were raised, the in vitro gelling capability rose. As the
polymer concentration grew, the rate and amount of drug release decreased.
Among all formulations tested, F4 with 4% w/v sodium alginate and 4% w/v
calcium carbonate had the highest in vitro drug release (95.6%) during a
12-hour period. There was no interaction between the medication and the excipients
utilised, according to FTIR measurements. The drug release from the
formulations followed first-order kinetics with Fickian diffusion.
Conclusion: Using sodium alginate, ciprofloxacin was effectively produced as a
pH-triggered floating in situ gelling system.
Author(s) Details:
Shailaja Pashikanti,
AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530003. Andhra Pradesh, India.
B. Jyothsna,
Pullareddy Institute of Pharmacy, Hyderabad, Telangana, India.
Please see the link here: https://stm.bookpi.org/CAPR-V2/article/view/6579
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