Understanding the Experiences of and Challenges Faced by LGBT+ Employees at Workplaces in India: Embracing Diversity and Inclusion | Chapter 10 | Recent Trends in Arts and Social Studies Vol. 8

 Objective: The objective concerning this study is to believe the experiences of and challenges confronted by LGBT+ employees at various workplaces in India.Introduction: Not many things belonging to gay, gay, epicene, and transgender (LGBT+) community are open about their similarity in society or at their business. There is scarcity of data on LGBT+ staff members at workplace in India accompanying very few employers encouraging alive hiring of the society or considering bearing policies in place for these things.Methods: A survey of 10 questions was conducted and solved by LGBT+ individuals the one are employees and now work in India. The employees of some type of organization were admitted to take the survey. The questionnaire probed into miscellaneous aspects of their knowledge at the workplace.Results: 103 things answered the survey. Only 17 (16.50%) responders out of 103 are entirely open about their sexual orientation when in fact 6 are partially open. 8 survey takers stated to have faced habitual skepticism after beginning about their sexuality at the workplace inasmuch as 16 out of 23 have confronted some form of bias. Only 18 survey takers said that they wish at hand out to their associates in the near future.Conclusion: Very few (16.50%) LGBT+ employees are open about their lust at the workplace. In a people where alternate preference of sexual partner is still a taboo, discrimination and badgering are likely to occur to these individuals. The study has certain restraints such as narrow sample size and further research is urged to build upon the consequences of this study. Hence, skilled is a need for protective laws for LGBT attendants.

Author(s) Details:

Abhay Mane,
Carlson School of Management, University of Minnesota, Minneapolis, MN 55454, USA.

Please see the link here: https://stm.bookpi.org/RTASS-V8/article/view/12038

Role of Physiotherapy in a Neonatal Intensive Care Unit: A Literature Review | Chapter 14 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The aim concerning this study is to review the composition on role of health care specialist in Neonatal Intensive Care Unit. Infants born prematurely or accompanying any difficulties in chest, neurobehavioral or musculoskeletal environments are admitted in Neonatal Intensive Care Unit (NICU) and distinguished care is taken of these babies according to their condition and complication. The need of the study search out know the various physiotherapy techniques secondhand in different environments and role of health care specialist in NICU. This is a narrative review related to role of health care specialist in neonatal intensive care unit. The drama search was done through miscellaneous search engines like Google scientist, PUBMED, Scihub, Chocraine and Science Direct. The articles in English vocabulary with inattentive to the year was included in the study and was precariously appraised. Total 112 items were screened for the study and 11 items were included in the study established inclusion tests. Among the article were screened, skilled were reviewed. Physiotherapists have alive role in NICU. During prematurity or environments like birth unconsciousness the physiotherapy in form of breast physiotherapy is important to improve the fresh air and reduce work of respiring. Physiotherapy in form of early provocation therapy or multisensory provocation helps in improving the neurobehavioral state of the baby and reduces the risk of any complications/ melancholy in the future or happening of the child.

Author(s) Details:

Dhwani Chanpura,
College of Physiotherapy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11996

Maternal Outcome in Referred Obstetric Patients | Chapter 13 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The purpose concerning this study was to authorize the pattern of obstetric referrals to Doon Female Hospital, government Doon Medical College, and to investigate the main cause for standard of comparison, causes of referral a delay, demonstrative course, manner of analysis, and outcomes of applied patients. The referral plan is a vital part of some medical situation system that focuses on furnishing women with wanted healthcare between the course of their gestation and delivery. It is a backward-looking observational study. All the applied obstetric cases were analyzed for the cause of referral, place of standard of comparison and outcome between of 6 months from October 2021 to March 2022. In our study we found total 486 obstetric sufferers were referred. Maximum applied patients were in the age group of 20-30 age and 61% referrals were from Dehradun district 12.96% of cases were deferred referrals. According to the findings, ignorance and ignorance are main contributors to poor gestation outcomes. The need of the moment is to train basic and secondary health management workers in essential and danger obstetric care in order to avoid gratuitous referrals and reduce the burden on after second care hospitals, in addition to to reduce the frequency of slowed referrals in order to increase maternal and before birth outcomes.

Author(s) Details:

Neetu Kochhar,
Department of Obstetrics and Gynaecology, Government Doon Medical College, Dehradun, Uttarakhand, India.

Monica Chauhan,
Department of Obstetrics and Gynaecology, Government Doon Medical College, Dehradun, Uttarakhand, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11995

A Novel Approach to Airway Management in Pierre Robin Syndrome with Bicuspid Aortic Valve | Chapter 12 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Pierre Robin Sequence (PRS) is a complex inborn syndrome with a dispassionate triad of micrognathia, glossoptosis and cleft tendency with or without diversified secondary abnormalities chief to the risk of upper ventilating pipe obstruction and difficulty in augmenting. It poses a great challenge to the anaesthesiologist all the while laryngoscopy and intubation making oxygenation and ventilation difficult. We report a case of 3.5yr male adolescent suffering from PRS along with cleft tendency, left renal agenesis, reciprocal CTEV, bilateral inguinal hernia, pectus carinatum, a hard bony structure in the jaws of vertebrates aortic valve posted for cleft partiality repair where favorable ventilation and intubation was done and communicable a tongue stitch in addition to nebulization and prone position aided to maintain airway all the while recovery.

Author(s) Details:

Shobha V.,
Department of Anesthesiology and Critical Care, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Saurabh Mittal,
Department of Anesthesiology and Critical Care, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

K. V. Rawat,
Department of Plastic Surgery, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11994

Addiction as a Sui Generis Force: An Opinion Overview | Chapter 11 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The ambition that drives addiction (severe meaning use disorders) is best understood as primary, not derivative of added, commonly experienced inspirations -- though addiction often starts with other ambitions. The term, “sui generis,” emphasizes this. Addiction includes an intense focus on utilizing, with a motivational salience to use repeatedly, and to engage in joined behavior, cognition, and purpose -- to the point that it takes over the user’s history, superceding common sense, reasonable doom, and acceptable behavior. Addiction is regularly accompanied by physical reliance, but is not the same thing: namely, using to avoid retraction is not the same as using to satisfy addictive craving. But material dependence or other ambitions may appear as “fake-addiction.” Addictive craving is not a subjective derivative of other motivations (though an follower will say otherwise). In allure pathogenesis, occasional alcohol or dependence on illegal substance becomes routine. Then, orderly use becomes a turning point for many, toward craving.

Author(s) Details:

Matthew B. Smith,
Psychiatrist Private Practice, New York, USA.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11993

Microsurgery Achievements for Regenerative Medicine Enhancement | Chapter 10 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Microsurgery has arose as a groundbreaking technique engaged of regenerative cure, offering unprecedented event for tissue repair and regeneration. This paper supports a comprehensive test of the advancements made in microsurgery and allure impact on regenerative cure. By conducting a all-encompassing review of existing literature, we survey the diverse applications and progressions in microsurgery methods that have significantly provided to the field of regenerative medicine.The item begins by discussing the classical context of educational medicine and its appropriate animal studies. It also elucidates the fundamental principles of microsurgery, emphasize its important role in enabling exact tissue manipulation at the tiny level. Furthermore, the article addresses current technological advancements that have threw microsurgery to new heights.Moving forward, we delve into the particular applications of microsurgery in educational medicine, focusing on key districts such as nerve repair, vascular anastomosis, tissue transplantation, and means reconstruction. We focal point the remarkable achievements and breakthroughs that microsurgery has helped in these domains.In conclusion, microsurgery has demonstrated important accomplishments in improving regenerative medicine. Therefore, further investigation and refinement of microsurgical techniques hold huge potential for revolutionizing enlightening medicine and ultimately reconstructing patient care.

Author(s) Details:

Kamran Shirbache,
Center for Orthopedic Trans-Disciplinary Applied Research (COTAR), Tehran University of Medical Sciences, Tehran, Iran.

Hossein Nematian,
Center for Orthopedic Trans-Disciplinary Applied Research (COTAR), Tehran University of Medical Sciences, Tehran, Iran.

Zahra Vahdati,
Center for Orthopedic Trans-Disciplinary Applied Research (COTAR), Tehran University of Medical Sciences, Tehran, Iran.

Nesa Milan,
Center for Orthopedic Trans-Disciplinary Applied Research (COTAR), Tehran University of Medical Sciences, Tehran, Iran.

Leila Oryadi Zanjani,
Iranian Tissue Bank and Research Center, Imam Khomeini Medical Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Masoumeh Firouzi,
Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.

Ali Shirbacheh,
Hospital Centre of Niort, Niort, France.

Mohammad Hossein Nabian,
Center for Orthopedic Trans-Disciplinary Applied Research (COTAR), Tehran University of Medical Sciences, Tehran, Iran and Iranian Tissue Bank and Research Center, Imam Khomeini Medical Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11992

The Relationship of Ascending Aortic Diameter at Dissection to Body Mass Index and Body Surface Area | Chapter 9 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Objective: The aim of our study search out observe the conventional diameter of the dissected climbing aorta  at the time of dissection, in addition to any potential equating between the width of the dissected aorta and body bulk index or body surface district.Methods: This study examines the cohort of sufferers who had resulting surgical procedures for escalating aortic dissection at our healing center between March 2014 and July 2021. The whole patient public consisted of 62 individuals. The study contained the examination of the aortic root, arch, climbing and descending aortic diameters as a whole individuals.   The study recorded cases of valvular illness, surgical procedures, Cardiopulmonary Bypass (CPB) period, and Total Circulatory Arrest (TCA) time. The cases' Body Surface Area (BSA) and Body Mass Index (BMI) were derived by utilizing their height and burden measurements.Findings: The most of the patients in the study were male, and the mean age of all the patients was 59.23 ± 11.74 (61.5) age. The mean diameter of the climbing aorta was determined expected 51.23 ± 7.75 (50). The body surface district (BSA) was measured expected 1.9 ± 0.19 (1.89)  m², but the body mass index (BMI) was premeditated to be 26.93 ± 4.2 (26.15) kg/m². At the time of critique, there was no statistically important link seen betwixt body surface district (BSA) or body mass index (BMI) and escalating aortic size.Results: The adulthood of the patients in the study were male, and the mean age of all the victims was 59.23 ± 11.74 (61.5) years. The mean width of the ascending aorta was persistent to be 51.23 ± 7.75 (50). The body surface district (BSA) was measured expected 1.9 ± 0.19 (1.89) m², but the body bulk index (BMI) was calculated expected 26.93 ± 4.2 (26.15) kg/m². At the time of dissection, there was no statistically important link seen 'tween body surface region (BSA) or body bulk index (BMI) and ascending aortic intensity.Conclusion: The average ascending aortic diameter event of dissection is about 50 mm. The 55 mm aortic size can not be the definitive opening for elective abscission. There is not a significant relationship betwixt the measured width of the dissected ascending aorta and the individual's crowd surface area (BSA) or carcass mass index (BMI).

Author(s) Details:

Mohammad Alsalaldeh,
Department of Cardiovascular Surgery, Pamukkale University, Denizli, Turkey.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11991

Immunization Delivery System in Private Sector of Developing Countries | Chapter 8 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Immunisation is a process of alive intervention in human body’s unrefined mechanism. After meticulous & carefully done organized research work, this invasive procedure was granted for humans. It is essential to act immunization process as per given directions plus protocols & accompanying due precautions. It’s desired to trail checklist based following & monitoring, wherever additional dose of vaccine is going on. Keeping these points in mind, this affiliate was written to get the measure of practices continuing in private sector.

Author(s) Details:

G. D. Mahra,
Department of Community Medicine, LNMC and RC, Bhopal, Madhya Pradesh, India.

Rituja Kaushal,
Department of Community Medicine, LNMC and RC, Bhopal, Madhya Pradesh, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11990

Dermal Fillers- The Essentials of This Highly Sought-After Elixir | Chapter 7 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Dermal something that takes up are a part of the cosmetic processes that are minimally invasive, active and feasible. Thus it is becoming well sought-after. The information of patient evaluation, types of fillers and needle techniques secondhand forms the basis of understanding the rapidly increasing market of these something that takes up.

Author(s) Details:

Taradevi P. V. Narayan,
Department of Oral and Maxillofacial Surgery, Vydehi Institute of Dental Sciences, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11989

Diagnostic & Prognostic Evaluation of Ayurvedic Rasa Pariksha (Gustatory Examination) WSR to Modern Gustometry | Chapter 6 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Rasa Pariksha is secondhand in Ayurveda to determine two together the disease's prognosis and allure diagnosis. This test was covered individually in Vimansthana and Indriyasthana by Acharya Charaka. Since two together senses employ the unchanging sort of receptors, taste and smell are connected. The synthetic communication of taste, that is released as a neurotransmitter, travels from the tongue's taste cells to the gustatory domain of the brain through cranial nerves. The language has many classes of receptors that each convey a singular signal to the brain, where it is elucidated as bitter or sweet. True taste misfortune is quite unusual. It has happened discovered and driven that ayurvedic Rasa pariksha is useful for identifying and foreseeing illnesses. The four taste features-sweet (with sucrose), pungent (with seasoning), sour (with citric acid), and bitter (accompanying quinine hydrochloride)-are judged in accordance with contemporary healing knowledge. To judge the specific loss of taste, up-to-date gustometry techniques containing magnitude matching, relating to space testing, and electrogustometry can be applied.

Author(s) Details:

Waghe S. D.,
Department of Roga Nidana, SRK Ayurvedic College Hospital, Bhopal, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11988

Role of Ayurvedic Shabda Pariksha (Auscultation) in Clinical Diagnosis of Diseases WSR to Modern Computerized Sound Analysis | Chapter 5 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Ayurvedic acharyas engage sound examination (Shabda Pariksha) as diagnostic limit for diagnosing the illnesses. In order to discover a specific medical state of the system, Acharya Charaka in Vimansthana submitted to investigate the bowel sounds, joint crepitation, and different unique sounds create in the body like cough and hiccups. In addition to this, old Ayurvedic academics have provided writings of number of medical states, in the way that Tamak shwasa (bronchial asthma), which results in audible snoring. Kussmaul's breathing, Maha Shwasa, precipitating a loud, audible puff. The whooping cough (Krukaj Kasa) leading to the distinctive whoop sound, while laryngitis, Swarabheda, causes hoarseness of voice. The well-behaved doctors could discover these coughing's qualitative hearing variations with ease. Around the experience, there are continuous efforts to digitally capture and analyze the cough sound. A future audile-based workshop diagnosis of cough should depend the examination of vomiting-related waveforms and spectrograms generated from electronic respiratory sound analysis. Further, Ayurveda holds the idea that each person has a different voice that is determined by the supremacy of the doshik body establishment. It has been seen and decided that sound examination concede possibility be utilized as a diagnostic form to identify afflictions and body phenotypes as described in Ayurveda.

Author(s) Details:

Waghe S. D.,
Department of Roga Nidana, SRK Ayurvedic College, Bhopal, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11987

Insights to Develop a New Formula of NAD+-Boosting Supplement by Integrating the Philosophy of Traditional Chinese into Western Medicine | Chapter 4 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The curtailed pools of nicotinamide adenine dinucleotide (NAD+) and subsequent decline in mitochondrial functions precede to many ageing-related disorders. Simultaneous renovation of cellular NAD+ and mitochondrial act may be a powerful healing approach in curing old individuals. However, studies reporting coordinated increases in the levels of NAD+ and mitochondrial activity are still to be made. Here, we report a orderly review of the available history to determine whether mixing Chinese concepts in plotting a Western-style medicine is an excellent planning to promote the advantageous effects of NAD+ supplements in treating age-accompanying phenotypes. We sought the potential benefits of few specific molecules (NAD+, nicotinic acid, urolithin A, pyrroloquinoline quinone) in reinforcing NAD+ anabolism and mitochondrial adeptness. Synergistic and antagonistic effects of these particles to treat ageing-accompanying disorders were considered. Finally, a Western-style NAD+-boosting supplement rule based on the “ruler, minister, assistant, and envoy” knowledge of traditional Chinese cure is proposed. The study's findings meant the role of NAD+, nicotinic acid, urolithin A, and pyrroloquinoline quinone as ruler, minister, assistant, and envoy, individually. Accordingly, a proper recipe is proposed to simultaneously reinforce NAD+ anabolism and mitochondrial accomplishment. The role of the proposed rule at multiple levels of institution, i.e., organelle, cell, means, and body, is still highlighted to demonstrate the appropriate beneficial belongings. We conclude that the suggested NAD+ supplement wields double-fold effects in reconstructing cellular energy rank because of allure simultaneous action on NAD+ absorption and mitochondrial performance. However, future studies, containing pre-clinical/clinical trials and bioinformatics reasonings, are crucial to authorize the proposed action of the supplement rule in achieving unending health benefits.

Author(s) Details:

Bamboo X. Z. Yan,
Australian Institute of Integrative Medicine, New South Wales, Australia.

Chi Zhang,
Australian Institute of Integrative Medicine, New South Wales, Australia.

Thombas Ebjer,
Australian Institute of Integrative Medicine, New South Wales, Australia.

Hina Asrar,
Dow University of Health Sciences, Karachi, Pakistan.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11986

Correlation of Cardiovascular Autonomic Functions with Thyroid Dys-Function in Adults by Cold Pressor Test: A Prospective Case-Control Study | Chapter 3 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The objective of the episode is to judge the cardiac autonomic status in adult hyperthyroid and hypothyroid victims by Cold Pressor Test (CPT) and to study the correlation middle from two points thyroid status and the autonomic functions managing cardiovascular (CV) system. Changes, in thyroid rank, have pronounced effects on cardiovascular scheme reflecting individual dysfunction and increased morbidity. Exact interplay between individual nervous activity and thyroid hormones is dubious. Prospective case–control study done by dispassionate examination and serum levels of (T3, T4 and TSH). Three groups hypothyroid, hyperthyroid and control group were classification and blood pressure (BP) answers to CPT were evaluated in these groups. Statistical analysis was acted using student’s t-test. In hypothyroidism, basic sympathetic tone is raised to compensate for thyroid birth control method deficiency, and this reduces reflex incitement of sympathetic whole during stress, which exhibits crippled sympatho - excitatory responses superior to aortic stiffness and opposition. This prevents fall in systolic pressure and further results in hypofunctioning of parasympathetic volume. Hence, rise in systolic BP after CPT sank but statistically insignificant (P > 0.05). In hyperthyroidism, the rise in systolic BP after CPT is considerably decreased (P < 0.01) that suggests unbalanced sympathovagal volume, i.e., diminished parasympathetic and sympathetic activity. In hypothyroidism, a meaningful rise in diastolic BP after CPT (P < 0.01) implies impaired response to testing receptors, over activity of beginning receptors and endothelial dysfunction resulting in increased minor resistance. In hyperthyroidism, rise in diastolic BP following in position or time CPT is insignificant (P > 0.05) which implies direct action of thyroid birth control method on vascular smooth muscles causing vasodilatation. In addition skilled is reduced vagal & agreeable activity. Thus, the study revealed thyroid dysfunction leads to sympathovagal inequality affecting cardiac unrestrained politically function.

Author(s) Details:

Sunita Milind Tiwale,
Department of Physiology, D. Y. Patil Medical College, Kolhapur, Maharashtra, India.

Padmaja Rajey Desai,
Department of Physiology, D. Y. Patil Medical College, Kolhapur, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11985

From Dormant to Deadly: How Epstein Barr Virus Triggers Cancer in Humans | Chapter 2 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 In the sphere of medical discovery, a serious revelation arose when Epstein Barr virus (EBV) was found in cultured Burkitt's lymphoma (BL), ultimate prevalent teens tumor in tropical Africa. This important discovery was defended by positive correlations middle from two points EBV and BL, exemplified apiece presence of antibodies against actin, intermediates filaments, distinct-stranded DNA, and histones in the sera of distressed patients. The unveiling concerning this connection breathed new existence into the exploration of cancer's potential inceptions.Burkitt's lymphoma, known for allure aggressive nature and hasty proliferation, can bring about devastating consequences alternatively promptly medicated, often resulting in oblivion within a old age. In this context, the present review endeavors to epitomize the comprehensive panorama of EBV's duty in the development of Burkitt's lymphoma in offsprings. Encompassing a thorough analysis of the dispassionate manifestations, terrestrial prevalence, pathogenesis, and oncology of the virus, this survey seeks to clear up the intricacies of this hardship.Drawing upon cutting-edge research in the rule of viral-induced malignancy, this endeavor aspires to offer a beautifully spun tapestry of knowledge. It aims to educate the landscape of EBV's impact, revealing the mosaic of factors that cause the genesis of Burkitt's lymphoma. By inquiring into the latest insights, this review aspires to precede for innovative approaches to the situation of this challenging ailment, holding the promise of a more brilliant future for those affected by this formidable condition.

Author(s) Details:

Mohammad Salim,
Department of Higher Education, S.G.S. Govt. Autonomous P.G. College, Sidhi, Madhya Pradesh, India.

Mohammad Shahid Masroor,
People’s College of Dental Science and Research Center, People’s University, Bhopal, Madhya Pradesh, India.

Shagufta Parween,
Department of Human Anatomy, All India Institute of Medical Science (AIIMS), Bhopal, Madhya Pradesh, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11984

Musculoskeletal Disorders Among Caregivers Handling Non-ambulatory Spinal Cord Injury Patients | Chapter 1 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Aim: To learn the prevalence of musculoskeletal problems in caregivers management non ambulatory sleep-inducer cord injury subjects and most common section of injury.Introduction: Loss of physical, emotional, and social performance can result from spinal rope injury, a difficult condition. Patients who experience aforementioned may be harshly disabled. They are dependent on caregivers for their common needs because of their deterioration. Caregiver types for spinal cord harms include offspring members and caregiver experts. It is vital to decide the prevalence of musculoskeletal difficulties because caring for SCI victims can be taxing on account of inadequate training and painful posture, which causes musculoskeletal questions in caregivers.Methods: A total of 80 caregivers, including family caregivers and caregivers working by organizations, aided in a cross-sectional research. Based on a practical sipping, a self-structured approved questionnaire was utilized to interview the caregivers. Descriptive enumerations were used to analyze the dossier.Results: The prevalence of musculoskeletal problems is 95% in caregivers containing both offspring and professional caregivers. Low back pain is the commonest site of manifestations (53%) followed by 15% narrow connector, 12% upper back pain, right shoulder (10%), right wrist (5%) and no pain (5%).Conclusion: Musculoskeletal issues are very accepted among caregivers of sufferers with non-ambulatory sleep-inducer cord harm. Back and neck discomfort are the two most usually impacted regions. The study's conclusions showed that appropriate preparation and exercise are necessary as a approach of avoiding musculoskeletal issues.

Author(s) Details:

Pranjali R. Kulkarni,
Sancheti Institute College of Physiotherapy, Shivajinagar, Pune, India.

Manish M. Ray,
Sancheti Institute College of Physiotherapy, Shivajinagar, Pune, India.

Ashok Shyam,
Sancheti Institute College of Physiotherapy, Shivajinagar, Pune, India.

Parag Sancheti,
Sancheti Institute College of Physiotherapy, Shivajinagar, Pune, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11983

Acridine and Acridinedione: Synthesis and Biological Applications | Chapter 11 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 The devote effort to something acridinediones has increased over the past various decades, which has unlocked the door to new applications in the technical, medical, and artificial domains. This is because acridinediones are an main class of nitrogen heterocyclic compounds that include excellent,4-dihydropyridine parent nucleus. This book episode covers the application of miscellaneous catalysts and methodologies, in the way that nanocatalysts, ionic fluids, microwaves, and ultrasound, in the development of synthetic contracts. It also specifies an overview of the historical framework, chemical backlashes, and physical and chemical traits of acridine/acridinedione derivatives. In addition, we have argued the results of the monomethoxy polyethylene glycol (mPEG) attached acridinedione compounds that were synthesized by our group and their organic applications, to a degree anticancer, antioxidant, and anti-microbial activity. The purpose concerning this discussion search out provide motivation for further search on the synthetic principles and mechanistic riddles associated with the acridinedione moiety for the improvement of mankind.

Author(s) Details:

Tathagata Dey,
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India and Department of Pharmaceutical Chemistry, East Point College of Pharmacy, Bangalore-560049, Karnataka, India.

Dhakshanamurthy Thirumalai,
Department of Chemistry, Thiruvalluvar University, Vellore-632 115, Tamil Nadu, India.

Srinivasan Parthiban Ragavi,
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India.

Indira Viswambaran Asharani,
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NACB-V7/article/view/11969

Cadaverine on Polymer Support: A Study on Solid Phase Synthesis | Chapter 10 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 In allure, solid-aspect synthesis is a method at which point molecules are covalently bound on a stable support material and synthesised step-by-step in a alone reaction ship utilising selective protecting group allure. Benefits compared accompanying normal combination in a liquid state include High efficiency and throughput and Increased candor and speed. The reaction maybe driven to accomplishment and high yields through the use of exuberance reagent. In this method, construction blocks are protected by any means reactive working groups. Cadaverine is a polyamine that naturally occurs and is carefully related to spermine and spermidine, two main polyamines that control the growth of living belongings. Cadaverine was created utilizing polystyrene as a solid support and a photocleavable linker. Filtration and washing with appropriate solvent are the only purification steps resorted to throughout the combining. Cadaverine was initially synthesized on a polystyrene support and therefore photolytically separated from the mold. Utilizing variously cross-connected polystyrene resins with divinyl benzene serve as the cross-linking agent, the yield and innocence of the sample were examined. One photocleavable linker's impact was examined. Linker was created utilizing a traditional organic artificial process.

Author(s) Details:

V. Santhakumari,
Department of Chemistry, Sree Narayana College, Kollam-691 001, India.

Please see the link here: https://stm.bookpi.org/NACB-V7/article/view/11968

Antimicrobial Cytidine Derivatives as Anticancer Agents with in Silico Studies | Chapter 9 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 The present study focuses on the computational inquiry of the antibacterial, anticancer, and construction-activity connection (SAR) properties of cytidine and allure analogs. Nucleosides are glycosylamines that can be thinking of as nucleotides without a phosphate group. A nucleoside exists simply of a nucleobase (more termed a nitrogenous base) and a five-element sugar (ribose or 2'-deoxyribose) when in fact a nucleotide is composed of a nucleobase, a five-element sugar, and individual or more phosphate groups. In a nucleoside, the anomeric carbon is connected through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the microscopic building blocks of DNA and RNA. Nucleoside analogs have a meaningful role in the drug and clinical areas as therapeutic powers and authorized pharmaceuticals. Microdilution persistent the modified analogs' completely clean activity, MIC, and MBC against human and phytopathogenic isolates. Compounds (7), (10), and (14) were ultimate potent against Escherichia coli and Salmonella abony strains, accompanying MIC and MBC values from 0.316 ± 0.02 to 2.50 ± 0.03 and 0.625 ± 0.04 to 5.01 ± 0.06 mg/ml, individually. The highest inhibitory venture was observed against grandam-positive microorganisms. Numerous analogs (10), (13), (14), and (15) exhibited good venture against the tested fungi Aspergillus niger and Aspergillus flavus. The anticancer project of the cytidine analogs was examined through an MTT colorimetric assay against Ehrlich’s ascites malignant growth (EAC) tumor containers, whereas compound 6 granted the maximum antiproliferative activity accompanying an IC50 value of 1168.97 µg/ml. Their microscopic docking studies against the urate oxidase 1R51 from A. flavus look at the binding mechanism, affinities, and nonbonding interplays to define this finding. The most of analogs bind more tightly than the original drug. The reinforced pharmacokinetic profile of cytidine analogs accompanying decreased severe oral toxicity was illustrated by in silico ADMET prediction, that was used to assess the drug-reproduction features. This research power result in the production of potential cytidine-based antimicrobial drug(s) established the in vitro and in silico results.

Author(s) Details:

Sarkar M. A. Kawsar,
Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh.

Please see the link here: https://stm.bookpi.org/NACB-V7/article/view/11967

A Study of Some New Chalcone Derivatives from Cholic Acid Based on Synthesis, Characterization, and Biological Activity | Chapter 8 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 Cholic acid, as known or named at another time or place 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary hostility acid that is insoluble in water (dissolved in alcohol and tart acid), it is a white crystalline stuff. Salts of cholic acid are called cholates. Cholic acid, in addition to chenodeoxycholic acid, is one of the two bigger bile acids created by the liver, place it is synthesized from cholesterol. N-(4-acetylphenyl)-3',7',12'-trihydroxy-5'-cholan-24-amide was synthesized from response of cholic acid with 4-amino acetophenone by utilizing DMAP as acatalyst and DCC as acoupling agent then the acquired product reacts accompanying some substituted benzaldehyde derivatives by utilizing NaOH as acatalyst to prepare chalcone descendants(3,4,5,6,7). Finally, the products (3,6) were admitted to react with thiourea accompanying presence alcoholic NaOH as a impetus with a reflex to present thiazine derivatives (8,9). All the chalcone descendants have weak to moderate activity against S. aureus, but all products show moderate to strong action against Candida albicans. The reactions were listened by thin-layer chromatography (TLC) technique. All the new compounds were from melting points, basic analysis, FT-IR, 1H NMR, 13C NMR spectroscopies. Antimicrobial activity of the combined derivatives was still determined.

Author(s) Details:

Nabeel A. Abdul-Reda,
Department of Chemistry, College of Science, University of Al-Qadisiyah, Al-Diwaniyah, Al-Diwaniyah Province, Iraq.

Abbas S. Abd,
Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Diwaniyah, Al-Diwaniyah Province, Iraq.

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Determination of Physicochemical Parameters and Structural Elucidation of Crab-shell Chitosan, and Antioxidant Activity Study of Oligochitosan-encapsulated Crab-shell Chitosan | Chapter 7 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 Chitin acquired after demineralization and deproteinization of pulverized crab structures was deacetylated in strictly salty medium of caustic soda to yield extreme molecular weight nano-lucid crab-shell chitosan (HMWNC) accompanying Mw of 350 kDa, 71% DDA, particle proportion of 76 nm, 7.4% moisture content and 1% ruins content. The current work involved encapsulation of marketing chitosan oligosaccharide (COS) with average Mw < 3000 Da and 87% DDA in HMWNC, and aforementioned an encapsulation of COS as a pharmaceutical ingredient into HMWNC was completed activity to bring about an augmentation in bioavailability of COS in target containers. This was revealed by greater in vitro antioxidant venture of HMWNC encapsulated chitosan oligosaccharide (COS-HMWNC) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC50 = 512.6±14.4 μg/mL) than COS and HMWNC accompanying less than 50% inhibition at 1000 μg/mL. The antioxidant t endeavor was found to increase accompanying the decrease in molecular burden and increase in DDA. The encapsulation of COS molecules in HMWNC was establish to provide accompanying a facile habit of enhancement in the antioxidant activity of COS.

Author(s) Details:

Hari Sharan Adhikari,
Department of Applied Sciences, Pashchimanchal Campus, Institute of Engineering, Tribhuvan University, Pokhara, Nepal.

Aditya Garai,
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India.

Bishnu Prasad Marasini,
Department of Biotechnology, National College, Tribhuvan University, Naya Bazar, Kathmandu, Nepal.

Rameshwar Adhikari,
Research Center for Applied Science and Technology, Tribhuvan University, Kathmandu, Nepal and Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal.

Paras Nath Yadav,
Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal.

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Analytical Method Development and Validation of Simultaneous Estimation of Ivermectin and Albendazole Byusing RP-HPLC | Chapter 6 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 A new arrangement was established for concurrent estimation of Ivermectin and Albendazole by RP-HPLC method. The chromatographic environments were successfully grown for the separation of Ivermectin and Albendazole by utilizing ACE C18 column (4.6×150 mm) 5µ, flow rate was 1.2 ml/min, travelling phase percentage was (70:30 v/v) methanol: Phosphate safeguard pH 3 (pH was adjusted with ortho phosphoricacid), discovery wavelength was 240 nm. The means used was WATERS HPLC Auto Sampler, Separation piece 2690, photodiode array detector 996, Empower-software variant-2. The retention periods were found expected 2.344 mins and 3.284 mins. The % purity of Ivermectin and Albendazole was found expected 101.27% and 99.97% respectively. The system rightness parameters for Ivermectin and Albendazole such as hypothetical plates and tailing determinant were found expected 4668, 1.3 and 6089 and 1.2, the resolution was found expected 6.0. The analytical means was validated in accordance with ICH guidelines (ICH, Q2 (R1)). The linearity study n Ivermectin and Albendazole was in the direction of concentration range of 50 µg-250 µg and 5µg-50µg and equivalence coefficient (r2) was erect to be 0.999 and 0.999, % recovery was erect to be 99.56% and 99.48%, % RSD for repeatability was0.2 and 0.2, % RSD for middle precision was 0.2 and 0.1respectively. The accuracy study was precise, robust, and repeatable.  LOD profit was 3.17 and 5.68, and LOQ value was 0.0172 and 0.2125 individually. Hence the suggested RP-HPLC pattern can be used for routine reasoning of Ivermectin and Albendazole in API and Pharmaceutical dosage form.

Author(s) Details:

Meruva Sathish Kumar,
MNR College of Pharmacy, Fasalwadi, Sangareddy, India.

Phani Deepika Polampalli,
MNR College of Pharmacy, Fasalwadi, Sangareddy, India.

Bandi Narendar,
MNR College of Pharmacy, Fasalwadi, Sangareddy, India.

S. Siva Prasad,
MNR College of Pharmacy, Fasalwadi, Sangareddy, India.

Rasapally Ramesh Kumar,
MLR College of Pharmacy, Dundigal, India.

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Excited State and Magnetic Study of Monochlorocopper(II)-N-(pyridine-2-yl) Picolinamidate Complex - A Computational Exploration | Chapter 5 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 Monochlorocopper(II)-N-(pyridine-2-yl) picolinamidate complex has happened produced from N-(pyridine-2-yl) picolinamide ligand. For the study of active properties of the upset state, TD-DFT calculations are ultimate reliable method. In order to accept the excited state character of the complex and involvement of ligand and ore parts in the excited state, Time-helpless Density Functional Theory (TD-DFT) calculations have happened carried out. In this study TD-DFT linked with LanL2DZ basis set and free formalism trailed.  Spin density and NBO forethoughts reveals the connection of added covalent individuality of ligand metal bond. From the NBO forethoughts it is observed that copper have a tetra-arrangement in the coordination ranges. The spin density on the law enforcement officer atom is not local and it is only 0.523 on copper and staying being distributed over two pyridine nitrogens (0.100, 0.106), amide nitrogen (0.174) and chloride minimum (0.101). A magnetic study of the copper complex has happened analysed using GIAO system.

Author(s) Details:

Raji Thomas,
Department of Freshmen Engineering, St. Martin’s Engineering College, Kompally, Hyderabad, Telangana, India.

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Synthesis and Characterization of Fe₂O₃, Fe₂O₃ @Ag, Fe₂O₃ @AC and Fe₂O₃ @Ag@AC NCs for Waste Water Treatment Applications | Chapter 4 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 The use of plant extracts as lowering agents grant permission be preferable to use of synthetic reduction reagent to combining of iron-based nanoparticles for utilizing in wastewater treatment. This present work defines a non-hazardous pattern for synthesizing iron group of chemical elements nanoparticles using Cocos nucifera L leaf extract. Through XRD it was determined that the material had a twelve inches/30.48 centimeters measured structure. UV–Vis incorporation spectrum of iron group of chemical elements nanoparticles (FeO-NPs) displays a peak in the region of 365- 375 nm. The average piece size, as contingent upon the XRD investigation, was 29–30 nm. Through the use of FESEM and TEM, rod-like nanostructures accompanying size decreases have happened discovered. The created Fe2O3, Fe2O3@Ag, Fe2O3@AC, and Fe2O3@Ag@AC NCs shown extreme photocatalytic activity distinguished to methylene blue dye. The explanation is that iron group of chemical elements and charcoal two together have properties that humiliate the absorption of difficult metals. These characteristics of the combined nanocomposite make it suitable for habit in water treatment conveniences, dye effluent eviction systems, and dye depravity systems.

Author(s) Details:

N. S. Mohan,
Department of Mechanical Engineering, Erode Sengunthar Engineering College, Erode-638057, India.

M. Aynul Rifaya,
Department of Chemical Engineering, Erode Sengunthar Engineering College, Erode-638057, India.

J. Manivannan,
Department of Mechanical Engineering, Erode Sengunthar Engineering College, Erode-638057, India.

V. Vijayalakshmi,
Crystal Growth Laboratory, Department of Physics, Erode Sengunthar Engineering College, Erode-638057, India.

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Biofunctional Textiles with Inclusion Complexes of Citronella Oil with β-Cyclodextrin | Chapter 3 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 Integrated cure delivery arrangements in biofunctional textiles can aid in the battle against vector-carried illnesses. Instead of utilizing DEET (N,N-diethyl-m-methylbenzamide), which has disadvantages such poisonous responses and skin damage, you can utilize unwelcome made from plants and oils. However, in accordance with some masters, there are instances place essential oils are useless because of issues accompanying uncontrolled release. This study look at how citronella lubricate (OC) complexed with -cyclodextrin (CD) controlled the demeanor of cotton (COT) and polyester (PES) fabrics. The findings show that covering cotton and polyester accompanying -cyclodextrin complexes enables control over the essential lubricate's release mechanism from the material. Optical microscopy, SEM, and FTIR were used to evaluate the aggregates created; UV spectroscopy was used to decide the yield of complex formation; and controlled release was completed activity in vitro. Oil complexation accompanying CD had a yield of 63.79%, and it was found that when used to textiles, the release, that had previously been calculated in seconds, had changed to hours. The judgments indicate that aggregates, when modified with synthetic crosslinking agents, perform to offer a potential basis for immobilizing oils and organizing their release.

Author(s) Details:

Manuel J. Lis,
Institute of Textile Research and Cooperation of Terrassa, Polytechnic University of Catalonia, C/Colom 15, Terrassa, 08222 Barcelona, Spain.

Óscar García Carmona,
Institute of Textile Research and Cooperation of Terrassa, Polytechnic University of Catalonia, C/Colom 15, Terrassa, 08222 Barcelona, Spain.

Carlos García Carmona,
Institute of Textile Research and Cooperation of Terrassa, Polytechnic University of Catalonia, C/Colom 15, Terrassa, 08222 Barcelona, Spain.

Fabricio Maestá Bezerra,
Textile Engineering, Federal University of Technology-Paraná, 635 Marcilio Dias St., Apucarana 86812-460, Parana, Brazil.

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