Cortisol is individual of the steroid hormone often applied as “stress biomarker” used in diagnosis of afflictions or disorder related to raised chronic stress, pituitary-adrenal, and hypothalamic, especially Cushing’s condition and Addison’s disease. It plays an important duty in regulating wide range of physiologic and pathological body process. Measurement of cortisol levels cruel blood, antitoxin or plasma and urine is usually performed in clinical workshops by utilizing various immunoassay methods.Salivary and sweat cortisol have drawn growing attention as they reflect biologically alive cortisol level and involve non-invasive savoring procedure. Whereas, measurement of cortisol in grass provides reliable news as it reflects cortisol level over the earlier period of 3-4 months (similar to glycated red body fluid test), which tells average glucose level over the past 2-3 months. The 11ß-hydroxysteroid hydrogenase-2 (11ß-HSD2) isoenzyme, which interconverts biologically alive cortisol to inactive cortisone, regulates cortisol absorption. Monitoring the cortisol-cortisone ratio is favor as the best indicator for acting people with adrenal ailments. High-performance liquid chromatography coupled with crew mass spectrometry (LC-MS/MS) is usually working for the simultaneous calculation of cortisol and cortisone reliably. Studies shown that skilled are no appreciable correlations middle from two points serum, saliva, or excretion cortisol levels and hair cortisol concentration. However, a antitoxin cortisol level comparison betwixt stimulated serum cortisol and salivary or excretion cortisol demonstrated a positive connections.
Author(s) Details:
Syed N. Alvi,
Environmental
Health Program, Department of Cell Biology, King Faisal Specialist Hospital and
Research Center, Riyadh, Saudi Arabia.
Please see the link here: https://stm.bookpi.org/ARBS-V4/article/view/12006
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