Correlation of Cardiovascular Autonomic Functions with Thyroid Dys-Function in Adults by Cold Pressor Test: A Prospective Case-Control Study | Chapter 3 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 The objective of the episode is to judge the cardiac autonomic status in adult hyperthyroid and hypothyroid victims by Cold Pressor Test (CPT) and to study the correlation middle from two points thyroid status and the autonomic functions managing cardiovascular (CV) system. Changes, in thyroid rank, have pronounced effects on cardiovascular scheme reflecting individual dysfunction and increased morbidity. Exact interplay between individual nervous activity and thyroid hormones is dubious. Prospective case–control study done by dispassionate examination and serum levels of (T3, T4 and TSH). Three groups hypothyroid, hyperthyroid and control group were classification and blood pressure (BP) answers to CPT were evaluated in these groups. Statistical analysis was acted using student’s t-test. In hypothyroidism, basic sympathetic tone is raised to compensate for thyroid birth control method deficiency, and this reduces reflex incitement of sympathetic whole during stress, which exhibits crippled sympatho - excitatory responses superior to aortic stiffness and opposition. This prevents fall in systolic pressure and further results in hypofunctioning of parasympathetic volume. Hence, rise in systolic BP after CPT sank but statistically insignificant (P > 0.05). In hyperthyroidism, the rise in systolic BP after CPT is considerably decreased (P < 0.01) that suggests unbalanced sympathovagal volume, i.e., diminished parasympathetic and sympathetic activity. In hypothyroidism, a meaningful rise in diastolic BP after CPT (P < 0.01) implies impaired response to testing receptors, over activity of beginning receptors and endothelial dysfunction resulting in increased minor resistance. In hyperthyroidism, rise in diastolic BP following in position or time CPT is insignificant (P > 0.05) which implies direct action of thyroid birth control method on vascular smooth muscles causing vasodilatation. In addition skilled is reduced vagal & agreeable activity. Thus, the study revealed thyroid dysfunction leads to sympathovagal inequality affecting cardiac unrestrained politically function.

Author(s) Details:

Sunita Milind Tiwale,
Department of Physiology, D. Y. Patil Medical College, Kolhapur, Maharashtra, India.

Padmaja Rajey Desai,
Department of Physiology, D. Y. Patil Medical College, Kolhapur, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11985