To label the potential targets that effectively bind with the Interleukin Receptor joined tyrosine kinase. Methods: We analysed the potential targets expected docked using AutoDock V4.2 spreadsheet. The database used to recapture the structure is Protein Data Bank (PDB) on (12/02/2021). The docking limits such as binding closeness and binding energy was persistent. The core docking score was anticipated when docking was acted and the results obtained from the binding parameters were distinguished with the berthing parameters results. From the Gas Chromatography-Mass Spectrometry results, we erect the potential targets to be anchored with the Interleukin Receptor helped tyrosine kinase. Findings: The targets 2-Propenoic acid, 3-phenyl-, ethyl ester, and hexadecanoic acid effectively rendezvoused with the receptor and foresees the binding energy (-5.83) and (-4.80). We are investigating the Artemisia pallens that is having good antidiabetic project and based on the citations, we found that Interleukin Receptor Associated Kinase is responsible for diabetes. Novelty/Improvement: From these inspections, we concluded that hexadecanoic acid, derived from Artemisia pallens, successively binds with the receptor and desires that it may be practicable to discover drugs in the future.
Author(s) Details:
K. Sai Pavithra,
Department
of Biotechnology, Thanthai Hans Roever College of Arts and Science, Affiliated
to Bharathidasan University, Perambalur, India.
Jeyanthi
Annadurai,
Department
of Biotechnology, Thanthai Hans Roever College of Arts and Science, Affiliated
to Bharathidasan University, Perambalur, India.
K. Ramanathan,
Department of Microbiology, Thanthai Hans Roever College of Arts and
Science, Affiliated to Bharathidasan University, Perambalur, India.
R. Ragunathan,
Centre for Bioscience and Nanoscience Research, Affiliated to
Bharathiar University, Coimbatore, India.
Please see the link here: https://stm.bookpi.org/ARBS-V4/article/view/11979
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