The severe toxicity and anxiolytic effects of hydroalcoholic Tapinanthus dodoneifolius, Bryophyllum pinnatum, and Terminalia catappa leaf extracts were checked. Limit dose severe toxicity testing in rodent was used to assess acute toxicity. The open-field example (OFT) was used to assess anxiolytic project after 1 moment of single spoken administration of water purified by distillation, extracts (at three dose levels), and diazepam (0. 5 mg/kg) utilizing the behavioral indications of mean centre zone time (CZT), centre zone re-access (CZR), and defeaction/urination repetitiveness (D/UF). Acute toxicity testing tells that the extracts are safe, accompanying an LD50 of 5g/kg. On the OFT paradigm, alone acute T. dodoneifolius and B.pinnatum extract situations demonstrated consistent prescription-dependency in anxiolytic action across the three parameters of mean CTZ, mean CZR, and mean MD/UF, accompanying T. catappa extract exhibiting prescription-dependent anxiolytic effect only on the first limit. At the maximum dosage level of 500 mg/kg, nevertheless, all plant extract treatments had anxiolytic belongings equivalent to 0.5 mg/kg diazepam treatments. The findings concerning this study justify the established use of medicinal plant extracts in the situation of neuropsychiatric illnesses.
Author(s) Details:
Umarudeen A. M.,
Department
of Pharmacology & Therapeutics, University of Abuja, Abuja, Nigeria.
Khan
F.,
Department
of Pharmacology & Therapeutics, Ahmadu Bello University, Zaria, Nigeria.
Please see the link here: https://stm.bookpi.org/NAPR-V9/article/view/11906
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