Pure Hair Nail Ectodermal Dysplasia in Two Yemeni Siblings | Chapter 2 | Advancement and New Understanding in Medical Science Vol. 4

We report two cases of PHNED in a 15 years old Yemeni boy, and his 2 months old sister, who were born with total absence of hairs and dystrophic 20 nails. Ectodermal dysplasias (ED) are a rare group of genodermatoses affecting tissues of ectodermal origin namely: hair, nails, teeth, and sweat glands. Pure hair, nail ectodermal dysplasias (PHNED) are very rare, and involve only hair and nails, while other ectodermal structures are intact. To date only 68 (35 male, 33 female) cases have been reported in the world literature [Table 1].  A genetic analysis would be of great help to determine the causative mutation in our case, but unfortunately this sophisticated tool is not available in most of the developing countries. We hope that a genetic analysis could be available in near future in all developing countries, as this will help confirming the genetic mutation causing all cases of PHNED as well as other forms of ED.

Author(s) Details:

Mohammad Ali Alshami,
Dermatology Department, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen.

Mona Jameel Mohana,
Dermatology Department, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen.

Ahlam Mohammad Alshami,
Faculty of Dentistry, Sana’a University, Sana’a, Yemen.

Please see the link here: https://stm.bookpi.org/ANUMS-V4/article/view/13172

Bioanalytical Methods for Cortisol Analysis | Chapter 13 | Advanced Research in Biological Science Vol. 4

 Cortisol is individual of the steroid hormone often applied as “stress biomarker” used in diagnosis of afflictions or disorder related to raised chronic stress, pituitary-adrenal, and hypothalamic, especially Cushing’s condition and Addison’s disease. It plays an important duty in regulating wide range of physiologic and pathological body process. Measurement of cortisol levels cruel blood, antitoxin or plasma and urine is usually performed in clinical workshops by utilizing various immunoassay methods.Salivary and sweat cortisol have drawn growing attention as they reflect biologically alive cortisol level and involve non-invasive savoring procedure. Whereas, measurement of cortisol in grass provides reliable news as it reflects cortisol level over the earlier period of 3-4 months (similar to glycated red body fluid test), which tells average glucose level over the past 2-3 months. The 11ß-hydroxysteroid hydrogenase-2 (11ß-HSD2) isoenzyme, which interconverts biologically alive cortisol to inactive cortisone, regulates cortisol absorption. Monitoring the cortisol-cortisone ratio is favor as the best indicator for acting people with adrenal ailments. High-performance liquid chromatography coupled with crew mass spectrometry (LC-MS/MS) is usually working for the simultaneous calculation of cortisol and cortisone reliably. Studies shown that skilled are no appreciable correlations middle from two points serum, saliva, or excretion cortisol levels and hair cortisol concentration. However, a antitoxin cortisol level comparison betwixt stimulated serum cortisol and salivary or excretion cortisol demonstrated a positive connections.

Author(s) Details:

Syed N. Alvi,
Environmental Health Program, Department of Cell Biology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Please see the link here: https://stm.bookpi.org/ARBS-V4/article/view/12006

A Study on the Muscle Immobility of Depression: the Weightlessness within | Chapter 11 | Novel Research Aspects in Medicine and Medical Science Vol. 2

 The aim concerning this study was to decide the function of bioelements in human depression. In the randomized, anticipated, observational trial, 311 adult colleagues (188 women and 123 men) had assessments for fur sodium and potassium; 192 were controls (83 men and 109 women), and 119 had meaningful unipolar depression (40 fellows and 79 women). Depression was diagnosed for one DSM-IV criteria, and wig sodium and potassium were analyzed by the inductively connected plasma nuclear emission spectroscopy (ICP AES). In the subgroup of 19 controls and 24 disadvantaged subjects who tried suicide (the serious form of major depression), antidiuretic birth control method (ADH) was assessed by utilizing the standard laboratory ADH diagnostic provisions. Significant gender distinctnesses were observed, since brothers have more hair Na and K than daughters (Na p < .01; K p < .02; Chi square test). The depressed cases also have increased levels of sideburn Na and K, what indicate the negative balance of these electrolytes, because hair growth is unidirectional (p < .01 for two together K and Na, Chi square test); ADH values were dropped off in the suicidal subgroup (p < .01, Chi square test). These findings on negative Na and K balance and lowered ADH in depression are related to those seen in astronauts during brief Apollo scope missions. The issue stands as to whether the stated Earthly metabolic changes of body powers in depressed cases are a direct result of muscle inactivity, or if cavity fatigue is mediated apiece failure of some hypothetic, gravity helpless muscle mobility mind control "dynamostat" that operates as well the fluid regulation center that manifests allure presence when being light in Space.

Author(s) Details:

S. Morovic,
Aviva Polyclinic, Trpinjska ul. 7, 10000, Zagreb, Croatia.

S. Drmic,
Department Psychiat, Univ Hosp Zagreb, Croatia and Department Hlth Studies, University Split, Croatia.

J. Morovic,
Center GW d.o.o. and Gestalty d.o.o, Zagreb, Croatia.

S. Brundic,
Institute for Research and Development of the Sustainable Res Syst (IRES), Zagreb, Croatia.

B. Momcilovic,
Institute for Research and Development of the Sustainable Res Syst (IRES), Zagreb, Croatia.

Please see the link here: https://stm.bookpi.org/NRAMMS-V2/article/view/11807