Synthesize and Characterization of Polyvinyl Chloride/Copolyester/Nanoclay Composite Nanofiber | Chapter 2 | Novel Aspects on Chemistry and Biochemistry Vol. 8

 In the current study, poly-vinyl chloride/copolyester/nanoclay composite nanofibers are generated and their shape is examined two together before and after UV irradiation. Nanotechnology is share to considerably increase, even revolutionize, many technology and manufacturing sectors: data processing, energy, any branch of natural science, medicine, homeland safety, food security, and transportation, between many others. Today's nanotechnology harnesses current progress in chemistry, physics, matters science, and biotechnology to constitute novel materials that have unique characteristics because their buildings are determined on the nanometer scale. Four haphazard copolyesters were prepared by the polycondensation response of diols namely 1,5-dihydroxyanthraquinone, 4,4’-oxybis (benzoic acid) and changeable chalcone diol. Four chalcone diols were produced by acid catalyzed Claisen-Schmidt reaction at range temperature. These haphazard copolyesters were elucidated by solubility tests and viscosity calculations. The FT-IR, 1H & 13C NMR techniques were applied to enact the repeating wholes present in the copolyester backbone. Tetrahydrofuran medium was spun utilizing an electrospinning technique to constitute a composite nanofiber made of polyvinyl chloride, copolyester, and nanoclay. The language rules of the nanofibers was studied with leafing through electron microscopy (SEM). These composite nanofibers are expected to be a more meaningful biomaterial in the future. Thus, we conclude that Nanofibers of the copolyester maybe efficiently invented by electrospinning method and these composite nanofibers are expected expected a potential biomaterial of greater meaning.

Author(s) Details:

S. Jasmine,
Department of Chemistry, Rajalakshmi Engineering College, Thandalam, Chennai-602105, India.

D. Reuben Jonathan,
Department of Chemistry, Madras Christian College, Tambaram, Chennai-600059, India.

J. Sidharthan,
Department of Chemistry, V.O. Chidambaram College, Tuticorin, Chennai-628008, India.

D. Roopsingh,
Department of Chemistry, Presidency College, Chennai-600005, India.

Please see the link here: https://stm.bookpi.org/NACB-V8/article/view/12310

A Study of Some New Chalcone Derivatives from Cholic Acid Based on Synthesis, Characterization, and Biological Activity | Chapter 8 | Novel Aspects on Chemistry and Biochemistry Vol. 7

 Cholic acid, as known or named at another time or place 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary hostility acid that is insoluble in water (dissolved in alcohol and tart acid), it is a white crystalline stuff. Salts of cholic acid are called cholates. Cholic acid, in addition to chenodeoxycholic acid, is one of the two bigger bile acids created by the liver, place it is synthesized from cholesterol. N-(4-acetylphenyl)-3',7',12'-trihydroxy-5'-cholan-24-amide was synthesized from response of cholic acid with 4-amino acetophenone by utilizing DMAP as acatalyst and DCC as acoupling agent then the acquired product reacts accompanying some substituted benzaldehyde derivatives by utilizing NaOH as acatalyst to prepare chalcone descendants(3,4,5,6,7). Finally, the products (3,6) were admitted to react with thiourea accompanying presence alcoholic NaOH as a impetus with a reflex to present thiazine derivatives (8,9). All the chalcone descendants have weak to moderate activity against S. aureus, but all products show moderate to strong action against Candida albicans. The reactions were listened by thin-layer chromatography (TLC) technique. All the new compounds were from melting points, basic analysis, FT-IR, 1H NMR, 13C NMR spectroscopies. Antimicrobial activity of the combined derivatives was still determined.

Author(s) Details:

Nabeel A. Abdul-Reda,
Department of Chemistry, College of Science, University of Al-Qadisiyah, Al-Diwaniyah, Al-Diwaniyah Province, Iraq.

Abbas S. Abd,
Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Diwaniyah, Al-Diwaniyah Province, Iraq.

Please see the link here: https://stm.bookpi.org/NACB-V7/article/view/11966

Novel Heterocyclic Fused Pyarzolequinolines: An Efficient Synthesis, DNA Binding Interaction and Antimicrobial Activity | Chapter 1 | Novel Aspects on Chemistry and Biochemistry Vol. 6

This unit reported a rapid and adept method for the combination of novel fused- pyarzolequinolines derivatives in tart acid aqueous television with quantitative yield. The combined compounds (2a) and (4a) interact with CT-DNA. Fused tetracyclic plans containing a quinoline core represent an important class of heterocyclic bioactive unrefined products and pharmaceuticals by way of their significant and wide-range biological properties. Several of these compounds have existed obtained accompanying diverse pharmacological and biological ventures, such as antiplasmodial, antifungal, antibacterial, powerful antiparasitic, antiproliferative, anti-swelling and anti-inflammatory exercises.In the present division, the synthesis of 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)quinolin-2-ol (2a)/(3a) and 3-(2-hydroxyquinolin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazole-1 carbothioamide(4a) were prepared in accordance with Claisen-Schmidt condensation, via abridgment of 2- hydroxyquinoline-3-carbaldehyde with ketones. All basic solvents used for the combining were of analytical grade. The TLC was acted on Baker-Flex silica gel 1B-F (1.55) plates using ethyl acetate and oil ether. Then finally, a, Q-unsaturated ketone (3) reacts accompanying hydrazine hydrate, phenylhydrazine and thiosemicarbazide obtained from the matching substituted fused-pyarzolequinolines. The proposed constructions of the products and characterizations combined compounds of the reactions were assured established the spectral data and synthetic evidences. Viscosity experiment is considered all at once of the least ambiguous and ultimate critical tests of a binding manner in solution in the absence of crystallographic building data. The newly combined compounds were characterized by basic analysis, IR, 1H-NMR, and Mass spectral dossier. The interaction of the chosen projectiles for weaponry with shin thymus-DNA (CT-DNA) was investigated exploiting electronic ranges, viscosity tests, and thermal denaturation studies. The absorbance range experienced bathochromic and hypochromic alterations upon binding to CT-DNA. The binding constant (Kb) present value of 5.3x104 M-1 for (2a) and 6.5x105 M-1 for (4a). The stickiness measurements indicated that the viscosities of sonicated bar like DNA fragments were increased. The recently synthesized compounds tested for antimicrobial venture and, from protocol shows sulfur containing carbothioamide compounds (4a) shown significant inhibitory project and also bind more strongly accompanying calf organ meat-DNA compared to (2a).

Author(s) Details:

Devappa S. Lamani,
Department of Chemistry, Prof. CNR Rao Research Center, Basaveshwar Science College, Bagalkot Karnataka, India.

Please see the link here: https://stm.bookpi.org/NACB-V6/article/view/11713

Natural and Synthetic Chalcones as Privileged Molecules with Antioxidant Activities | Book Publisher International

Reactive oxygen species (ROS) in higher concentrations damage cells and deform molecules of a protein, lipid, or macromolecular nature. Maintaining cell homeostasis is intimately tied to maintaining a balance between ROS formation and elimination. Antioxidants are chemicals that can neutralise ROS's harmful effects. These substances are both artificial and organic. Flavonoids are a class of substances with strong antioxidant potential. Chalcones stand out among them due to their many biological characteristics, many of which are reliant on their antioxidant potential. The two aromatic subunits (aldehyde and acetofenone)' substituents (hydroxy and methoxy groups being necessary) have an impact on the type and position of this characteristic. Hybrid compounds with improved antioxidant capabilities can also be created by substituting an aromatic component with a heterocycle (such as isoxazole).

 

Author (s) Details

Teodora Constantinescu

Department of Chemistry, Faculty of Pharmacy, Iuliu Hatieganu University, 400012 Cluj-Napoca, Romania.

 

View Book :-  https://stm.bookpi.org/NSCPMAA/article/view/7755

Pharmacological Evaluation and Characterization of Synthesis Chalcones and Its Derivatives| Chapter 13 | Challenges and Advances in Pharmaceutical Research Vol. 2

Chemistry, sometimes known as medicinal chemistry, is a branch of chemistry that deals with the design, methodization, and creation of drugs. The name chalcones refers to intensifiers that contain the (E)-1,3-diphenylprop-2-en-1-one, which can be functionalized in the propane chain by the presence of olefinic, keto, and hydroxyl groups. Chalcones are a prominent family of natural products that are precursors of flavonoids and isoflavonoids. Is (E)-1,3-diphenylprop-2-en-1-one, a synthetic compound in which two aromatic ring rings are linked by a three-carbon bond with a carbonyl moiety and, unsaturation. Antimicrobial, anti-inflammatory, analgesic, anti-platelet, anti-ulcerative, antimalarial, anticancer, antiviral, anti-leishmanial, antioxidant, antitubercular, anti-hyperglycemic, immunomodulatory, inhibition of chemical mediators release, inhibition of leukotriene B4, inhibition of tyrosinase, and inhibition of aldose reductase activities are among the pharmacological activities of compounds with The major focus of this work is on chalcones produced via Claisen Schmidt condensation, which includes the condensation of an aromatic aldehyde or ketone with an aliphatic ketone or aldehyde in the presence of a dilute alkali or acid to generate an alpha beta unsaturated molecule. Various biological implications of chalcones and their derivatives have been documented, as well as their antibacterial activity against Bacillus pumilis, Bacillus subtilis (gram-positive) and Escherichia coli, Proteus vulgaris (gram-negative). Using a carrageenan-activated rodent paw oedema approach, the antiinflammatory activity of the sixteen chalcones was evaluated.

 

Author(s) Details:

Geeta Lodhi,
R.K.D.F. College of Pharmacy, SRK University Bhopal, Madhya Pradesh, India.

Amit Nayak,
R.K.D.F. College of Pharmacy, SRK University Bhopal, Madhya Pradesh, India.

Please see the link here: https://stm.bookpi.org/CAPR-V2/article/view/6585

Kinetic and Mechanistic Study of Oxidation of Chalcones by Morpholinium Chlorochromate with Oxalic Acid as Catalyst | Chapter 06 | Challenges and Advances in Chemical Science Vol. 8

 In a 55 percent acetic acid-water (v/v) media, the kinetics of chalcone oxidation by morpholinium chlorochromate (MCC) were investigated. The reactions were carried out under pseudo-first-order conditions, with the substrate concentration constantly above MCC. The reaction had unit order dependence for the oxidant and catalyst, as well as fractional order reliance for the substrate and H+ ion. The reaction rate is unaffected by increased ionic strength. The order of substitution in substituted chalcones with regard to substrate varies depending on the type of the substituent present in the ring. In general, electron removing substituents slow down the process, whereas electron releasing substituents speed up the reaction. The activation parameters have been estimated using the kinetic data, and a suitable mechanism has been proposed.

Author(S) Details

K. Rajalakshmi
Department of Chemistry, Shrimati Indira Gandhi College (Affiliated to Bharathidasan University), Tiruchirappalli 620 002, Tamilnadu, India.

View Book:- https://stm.bookpi.org/CACS-V8/article/view/5630

An Advanced Study on Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications | Chapter 8 | Current Perspectives on Chemical Sciences Vol. 7

Using cyclic, differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon electrode, a simple and rapid method was developed. Two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about −0.689 V could be generated by Chalcone. The differential pulse voltammerty has a strong linear response in the range of 0.2 - 10 μM with a detection limit of 0.18 μM compared to square wave voltammetry. The suggested approach has been successfully used as actual samples for its quantitative determination in spiked human plasma and urine. The suggested method provided the benefits of precision and time saving as well as reagent and apparatus simplicity. Furthermore, the findings obtained in the chalcone analysis of spiked human plasma and urine samples showed the applicability of the procedure for the analysis of actual samples.

Author (s) Details

Dr. Keerti M. Naik
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad, India.

Dr. Sharanappa T. Nandibewoor
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad, India.

View Book :- https://stm.bookpi.org/CPCS-V7/issue/view/5

Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products | Chapter 2 | Current Perspectives on Chemical Sciences Vol. 2

 The present study seeks to investigate the synthesis and structural characteristics of derivatives of Indanone, Tetralone and Naphthone. Via Claisen condensations, arylhydrazine condensations, BakerVenkataraman rearrangements, Claisen-Schmidt reactions, selective fluorinations and trifluoroacetylations in yields ranging from 22-92 percent, indanone, tetralone and naphthone derivatives and fused-ring heterocycles were prepared. Regiochemistry and stereochemistry observed in these products and their usefulness as scaffolds for the preparation of heterocyclic derivatives are of particular interest. Unusual changes such as a novel one-pot, dual trifluoroacetylation, trifluoroacetylnaphthone synthesis via deacetylation and an exchange of the acetyltrifluoroacetyl group are also noted. Using crystallographic methods, solid-state structural features exhibited by these compounds were investigated. In addition , this study will concentrate on the selective introduction of fluorine and fluorine-containing groups into these heterocyclic materials. In the near future , we expect these results to be announced.

Author(s) Details

Paul D. Boyle
Department of Chemistry, Western University, 1151 Richmond St., London, Ontario, N6A 5B7, Canada.

David Breaud
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Matthew Churley
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Patrick Coppock, Jr.
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Elvia Encarnacion-Thomas
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Chloe Fernandes
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Augustus W. Fountain
Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street Columbia, SC 29208, USA.

Cristina Gomez
Department of Chemistry and Life Science, United States Military Academy, 646 Swift Road, West Point, NY 10996, USA.

Alejandro Guzman
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

James L. Jackson
US Army Corps of Engineers, 101 West Oglethorpe Avenue, Savannah, GA 31401, USA.

Linh Lam
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Ajay Mallia
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Samantha Moseley
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Sang H. Park
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

William F. Pearman
Department of Chemistry and Life Science, United States Military Academy, 646 Swift Road, West Point, NY 10996, USA.

Robert D. Schmidt
Department of Chemistry, North Carolina State University, P.O. Box 8204, Raleigh, NC 27695, USA.

Joseph C. Sloop
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Roger D. Sommer
Molecular Education, Technology, and Research Innovation Center, North Carolina State University, 2620 Yarbrough Dr., Raleigh, NC 27695, USA.

Stephanie Stalker
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Jonathan Weyand
Department of Chemistry and Life Science, United States Military Academy, 646 Swift Road, West Point, NY 10996, USA.

Karla Wilmott
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

Jonathan Yi
School of Science and Technology, Georgia Gwinnett College, 1000 University Center Lane, Lawrenceville, GA 30043, USA.

 

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/302

Scientific Overview of Synthesis and Antimicrobial Evaluation of Novel 3-(thiophen-2-yl) -Pyrazoline-5-yl Derivatives | Chapter 5 | Trends in Pharmaceutical Research and Development Vol.3

Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were
synthesised from chalcone-like intermediate and substituted phenyl hydrazines, hydrazine hydrate,
and semi/thiosemicarbazide. The chemical structure of compounds was confirmed by means of IR,
1
HNMR, mass spectroscopy, and elemental analysis. The antimicrobial activities (antibacterial and
antifungal activities) of the synthesized compounds were evaluated against Staphylococcus aureus,
Staphylococcus faecalis, Escherichia coli, Salmonella typhi, and Candida albicans by agar diffusion
cup plate method. Compound IId (5-[(4-chlorophenyl)-1-(4-methoxyphenyl)]-3-thiophen-2-yl)-4,5-
dihydro-2-pyrazoline), IIg (5-(4-chlorophenyl)-1-(2-methylphenyl)-3-(thiophen-2-yl)-4,5-dihydro-2-
pyrazoline) showed very good activity. IIi (5-(4-chlorophenyl)-1-thiocarbamoyl-3-(thiophen-2-yl))-2-
pyrazoline), IIj (5-(4-chlorophenyl)-1-carbamoyl-3-(thiophen-2-yl))-2-pyrazoline) exhibit mild to
moderate inhibitory response against all the tested microbial strains. Compound IId shows excellent
significant zone of inhibition (mm) against all the species of microbes, thereby producing promising
antimicrobial respectively.

Author(s) Details

Dr. Biswajit Dash,
Himalayan Pharmacy Institute, Majhitar, Sikkim - 737136, India.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/222