Synthesis, Characterization, and Antioxidant Evaluation of Novel Ethoxylated Pyrazoline Derivatives: Promising Molecules for Drug Design in Pharmaceutical and Chemical Industries | Chapter 6 | Advanced Concepts in Pharmaceutical Research Vol. 7

 Pyrazolines are the most important class of compounds in the pharmaceutical and chemical industries and (are considered) the most promising molecules for the design of new drugs. In this study, eleven novel ethoxylated pyrazoline derivatives were synthesized by condensing chalcones with an ethoxy group and hydrazine hydrate in the presence of alcohol, highlighting their significance as promising molecules for drug design in the pharmaceutical and chemical industries. The synthesized compounds underwent thorough characterization using 1H NMR, 13C NMR, and mass spectra. Evaluation of these compounds for in vitro antioxidant activity through 2,2’-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide assay methods revealed moderate to good antioxidant properties. Notably, the compound EH2, with a methoxy group, displayed potent antioxidant activity with IC50 values of 9.02 and 9.44µg/ml, while EH9, featuring a hydroxy group, exhibited significant antioxidant activity with IC50 values of 12.41 and 14.56µg/ml in DPPH and hydrogen peroxide assays, respectively, surpassing the standard. Compounds containing electron-donating substituents demonstrated superior antioxidant capabilities compared to the standard ascorbic acid.

Author(s) Details:

B. Lakshminarayanan,
Department of Pharmaceutical Chemistry & Analysis, Sanjo College of Pharmaceutical Studies, Vellappara, Palakkad, Kerala – 678 702, India.

Vijayakumar B.,
Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Athalur, Kodunthirapully, Palakkad, Kerala – 678 612, India.

P. Parthiban,
Department of Pharmaceutical Chemistry, Vellalar College of Pharmacy, Maruthi Nagar, Thindal, Erode, Tamil Nadu – 638 012, India.

N. Kannappan,
Department of Pharmacy, Annamalai University, Chidambaram - 608002, Tamilnadu, India.

Please see the link here: https://stm.bookpi.org/ACPR-V7/article/view/13544

Scientific Overview of Synthesis and Antimicrobial Evaluation of Novel 3-(thiophen-2-yl) -Pyrazoline-5-yl Derivatives | Chapter 5 | Trends in Pharmaceutical Research and Development Vol.3

Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were
synthesised from chalcone-like intermediate and substituted phenyl hydrazines, hydrazine hydrate,
and semi/thiosemicarbazide. The chemical structure of compounds was confirmed by means of IR,
1
HNMR, mass spectroscopy, and elemental analysis. The antimicrobial activities (antibacterial and
antifungal activities) of the synthesized compounds were evaluated against Staphylococcus aureus,
Staphylococcus faecalis, Escherichia coli, Salmonella typhi, and Candida albicans by agar diffusion
cup plate method. Compound IId (5-[(4-chlorophenyl)-1-(4-methoxyphenyl)]-3-thiophen-2-yl)-4,5-
dihydro-2-pyrazoline), IIg (5-(4-chlorophenyl)-1-(2-methylphenyl)-3-(thiophen-2-yl)-4,5-dihydro-2-
pyrazoline) showed very good activity. IIi (5-(4-chlorophenyl)-1-thiocarbamoyl-3-(thiophen-2-yl))-2-
pyrazoline), IIj (5-(4-chlorophenyl)-1-carbamoyl-3-(thiophen-2-yl))-2-pyrazoline) exhibit mild to
moderate inhibitory response against all the tested microbial strains. Compound IId shows excellent
significant zone of inhibition (mm) against all the species of microbes, thereby producing promising
antimicrobial respectively.

Author(s) Details

Dr. Biswajit Dash,
Himalayan Pharmacy Institute, Majhitar, Sikkim - 737136, India.

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