Dilemma of Diagnosis between SJS and TEN Syndrome: Adverse Drug Reaction Caused by Terbinafine | Chapter 8 | New Visions in Medicine and Medical Science Vol. 7

The primary objective of this case report is to bring awareness among medical professionals regarding the potential cutaneous adverse reactions that may occur during the administration of terbinafine. SJS and TEN are uncommon, severe skin reactions characterized by extensive loss of skin and mucosal tissue, often accompanied by systemic symptoms. In more than 80% of cases, medications are identified as the causative agent for these reactions. SJS-TEN overlap syndrome is a very rare but severe cutaneous adverse drug reaction that is caused by terbinafine administration. We report a case of a 45-year-old female patient, with a documented history of uncontrolled diabetes and currently on medications, Metformin and Glimepiride, was admitted to a tertiary care hospital. The patient was suffering from vulvovaginal infection for which she was consuming terbinafine which led to the occurrence of cutaneous eruptions, across the right and left lower limbs, face, upper limbs, chest, back, arms, and abdomen, affecting almost the entire body covering 10- 30% of the body surface which makes it to fall under the category of SJS-TEN overlap syndrome. Even though terbinafine is thought to be safe, it can cause extremely serious adverse drug reactions, thus while prescribing it, appropriate safety measures must be performed. Patients having a history of drug reactions should not take the medication. The primary objective of this case report is to raise awareness among healthcare professionals about the potential for severe cutaneous drug responses induced by terbinafine and to instill vigilance in them regarding potential risks.

Author(s) Details:

Aparna Matpathi,
CMR College of Pharmacy, Aditi Womens Hostel, Amba Towers, Street Number 14, Himayat Nagar, 500029, Hyderabad, Telangana, India.

Shagupta Shalu,
CMR College of Pharmacy, Aditi Womens Hostel, Amba Towers, Street Number 14, Himayat Nagar, 500029, Hyderabad, Telangana, India.

Mokirala Niveditha,
General Medicine, Gandhi Medical College, Secunderabad, 500003, Hyderabad, Telangana, India.

Please see the link here: https://stm.bookpi.org/NVMMS-V7/article/view/14225

The Relationship of Ascending Aortic Diameter at Dissection to Body Mass Index and Body Surface Area | Chapter 9 | Novel Research Aspects in Medicine and Medical Science Vol. 3

 Objective: The aim of our study search out observe the conventional diameter of the dissected climbing aorta  at the time of dissection, in addition to any potential equating between the width of the dissected aorta and body bulk index or body surface district.Methods: This study examines the cohort of sufferers who had resulting surgical procedures for escalating aortic dissection at our healing center between March 2014 and July 2021. The whole patient public consisted of 62 individuals. The study contained the examination of the aortic root, arch, climbing and descending aortic diameters as a whole individuals.   The study recorded cases of valvular illness, surgical procedures, Cardiopulmonary Bypass (CPB) period, and Total Circulatory Arrest (TCA) time. The cases' Body Surface Area (BSA) and Body Mass Index (BMI) were derived by utilizing their height and burden measurements.Findings: The most of the patients in the study were male, and the mean age of all the patients was 59.23 ± 11.74 (61.5) age. The mean diameter of the climbing aorta was determined expected 51.23 ± 7.75 (50). The body surface district (BSA) was measured expected 1.9 ± 0.19 (1.89)  m², but the body mass index (BMI) was premeditated to be 26.93 ± 4.2 (26.15) kg/m². At the time of critique, there was no statistically important link seen betwixt body surface district (BSA) or body mass index (BMI) and escalating aortic size.Results: The adulthood of the patients in the study were male, and the mean age of all the victims was 59.23 ± 11.74 (61.5) years. The mean width of the ascending aorta was persistent to be 51.23 ± 7.75 (50). The body surface district (BSA) was measured expected 1.9 ± 0.19 (1.89) m², but the body bulk index (BMI) was calculated expected 26.93 ± 4.2 (26.15) kg/m². At the time of dissection, there was no statistically important link seen 'tween body surface region (BSA) or body bulk index (BMI) and ascending aortic intensity.Conclusion: The average ascending aortic diameter event of dissection is about 50 mm. The 55 mm aortic size can not be the definitive opening for elective abscission. There is not a significant relationship betwixt the measured width of the dissected ascending aorta and the individual's crowd surface area (BSA) or carcass mass index (BMI).

Author(s) Details:

Mohammad Alsalaldeh,
Department of Cardiovascular Surgery, Pamukkale University, Denizli, Turkey.

Please see the link here: https://stm.bookpi.org/NRAMMS-V3/article/view/11991