In the twenty-first century, pathogen resistance is a severe worry for health care, and efficient vaccinations to prevent life-threatening infections are desperately needed. Pathogens have been researched for their potential utility as therapeutic or preventative vaccines in order to discover novel antigens with diagnostic and vaccination potential. The current study used five distinct types of antigens derived from a single pathogen. It also highlights the immune complex and DNA antigen as the best candidates for pathogen vaccine development. During the course of infection, antigens may fluctuate inside the host, as well as antigenic kinds of parasites in the population. Antigenic variation is a key strategy employed by pathogenic microorganisms to avoid the antibody's neutralising and escape actions. Immune complexes and DNA antigens can be utilised as vaccinations, and they can also be employed to construct multi-antigen vaccines. It is also simple to manufacture on a wide scale. Vaccination remains the most effective method of preventing bacterial infections. Using Swiss albino mice (Balb/C) as experimental species, the conditions for preparing antigens of complete natural composition and conformation from Escherichia coli (whole cell and heat killed) were found. A unique vaccine design and production strategy is explored. The fundamental aim behind vaccination technology is to inhibit pathogen escape mechanisms by removing the components that contribute to disease.
Author(s) Details:
P. Dhasarathan,
Department of Biotechnology, Pratyusha Engineering College,
Tiruvallur-602025, India.
M. Thenmozhi,
Department of Biotechnology, Pratyusha Engineering College,
Tiruvallur-602025, India.
Lighty George,
Department of Zoology, Sarah Tucker College, Palayamkottai -627007, India.
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