The purpose of this study was to determine the prevalence of the +276 G/T polymorphism in the AdipoQ gene in menopausal Punjabi women with and without a family history of cardiovascular disease (CVD), as well as whether a positive family history of CVD has any specific independent effect on cardiovascular disease in menopausal Punjabi women. The Sri Guru Ram Das Institute of Medical Sciences and Research in Amritsar, Punjab, recruited 265 menopausal women with CVD as cases and 258 menopausal women without CVD as controls (India). The relationship between ADIPOQ SNPs, adiponectin levels, and cardiometabolic illnesses could be hampered by a number of causes or mechanisms. Family history prevalence varies depending on the age at which it is assessed. CVD aggregation in families may be linked to the accumulation of specific risk factors, such as those listed above, or specific behaviours, like as smoking and alcohol consumption, which may be influenced by hereditary and environmental variables. In cases with positive familial h/o of CVD, the TT genotype of recessive model of inheritance gave a 6-fold increased risk of CVD compared to controls, according to the study. The prevalence of the TT genotype was observed to be higher in cases than controls in both women with and without family history of CVD. To reduce illness burden, new treatment strategies can be created. Furthermore, there is a pressing need for a stronger public health-care system.
Author(S) Details
Jyot Amrita
Department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab-143001, India.
A. J. S. Bhanwer
Department of Genetics, Sri Guru Ram Das University of Health Sciences, Amritsar, Punjab-143001, India.
A. P. Singh
Department of Anesthesia, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.
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