Cellular Plasticity in Cancer: Adaptive Mechanisms Driving Progression and Evasion | Chapter 2 | Achievements and Challenges of Medicine and Medical Science Vol. 8

Background: Cellular plasticity refers to the ability of cells to adapt their characteristics, including phenotype and function, in response to environmental changes. This ability is vital for normal physiological processes, such as embryonic development, tissue regeneration, and immune responses. However, cellular plasticity plays a pathologically significant role in cancer, where it complicates treatment efforts and contributes to disease progression.

Objective: The objective of the study is to explore the role of cellular plasticity in cancer progression, with a particular focus on the plasticity of the epithelial-to-mesenchymal transition (EMT) and its impact on therapeutic strategies.

Methods: The study synthesizes current research on the mechanisms of cellular plasticity in cancer, including the genetic mutations and epigenetic alterations that lead to disrupted cellular functions. Special attention is given to the challenges posed by the plastic nature of EMT in developing effective cancer therapies.

Results: Cancer progression involves a multistep process characterized by the accumulation of genetic and epigenetic changes. These changes drive cellular plasticity, facilitating the adaptation of cancer cells to diverse environments and contributing to therapy resistance. Traditional cancer treatments often target specific states associated with epithelial or mesenchymal phenotypes, but the dynamic plasticity of cancer cells undermines the effectiveness of such approaches.

Conclusion: The plasticity of cancer cells, particularly through EMT, presents significant obstacles to conventional cancer therapies. Continued research is essential to develop innovative treatment strategies that account for cellular plasticity, with the ultimate goal of improving survival rates and the quality of life for cancer patients.

 

Author (s) Details

 

Aggarwal Roopak
Department of Pathology, University of Medical Sciences, Saifai, Uttar Pradesh, India.

 

Singh Natasha
Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, New Delhi, India.

 

Mishra Jyoti
Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, New Delhi, India.

 

Pandey Pinki
Department of Pathology, University of Medical Sciences, Saifai, Uttar Pradesh, India.

 

Joshi Himanshu
Department of Pathology, University of Medical Sciences, Saifai, Uttar Pradesh, India.

 

Kannaujia Sanjay
Department of Pathology, University of Medical Sciences, Saifai, Uttar Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v8/3479

Prevalence of Gene Polymorphism for Menopausal Women with Cardiovascular Disease: A Study from Punjab, India | Chapter 20 | Issues and Developments in Medicine and Medical Research Vol. 6

 The purpose of this study was to determine the prevalence of the +276 G/T polymorphism in the AdipoQ gene in menopausal Punjabi women with and without a family history of cardiovascular disease (CVD), as well as whether a positive family history of CVD has any specific independent effect on cardiovascular disease in menopausal Punjabi women. The Sri Guru Ram Das Institute of Medical Sciences and Research in Amritsar, Punjab, recruited 265 menopausal women with CVD as cases and 258 menopausal women without CVD as controls (India). The relationship between ADIPOQ SNPs, adiponectin levels, and cardiometabolic illnesses could be hampered by a number of causes or mechanisms. Family history prevalence varies depending on the age at which it is assessed. CVD aggregation in families may be linked to the accumulation of specific risk factors, such as those listed above, or specific behaviours, like as smoking and alcohol consumption, which may be influenced by hereditary and environmental variables. In cases with positive familial h/o of CVD, the TT genotype of recessive model of inheritance gave a 6-fold increased risk of CVD compared to controls, according to the study. The prevalence of the TT genotype was observed to be higher in cases than controls in both women with and without family history of CVD. To reduce illness burden, new treatment strategies can be created. Furthermore, there is a pressing need for a stronger public health-care system.

Author(S) Details

Jyot Amrita
Department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences & Research, Amritsar, Punjab-143001, India.

A. J. S. Bhanwer
Department of Genetics, Sri Guru Ram Das University of Health Sciences, Amritsar, Punjab-143001, India.

A. P. Singh
Department of Anesthesia, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.

View Book:- https://stm.bookpi.org/IDMMR-V6/article/view/5694